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Fri, 24 Nov 2017
Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets
Intrinsically disordered proteins (IDPs) play key roles in signaling and regulation. Many IDPs undergo folding upon binding to their targets. We have proposed that coupled folding and binding of IDPs generally follow a dock-and-coalesce mechanism, whereby a segment of the IDP, through diffusion... more »