Bioinformatics Platform for Clinicians and Industry

Our expertise is well suited to answer specific questions in the following disciplines:

I need the most appropriate computational algorithms for analysis of massive genomics, transcriptomics and proteomics data.

I need a comprehensive analysis and integration of massive data generated by deep sequencing, any micrarray platforms and mass spectrometry experiments.

I need to integrate diverse clinical and wet-lab data sets and genomics information into user-friendly data bases.

I need a deep computational statistical analysis which could help to identify biologically important components and modules of complex biomedical systems (e.g, key pathways, gene markers, potential drug targets).

I need to quantify clinically important information for optimization of personal medicine strategies (including patient' individual prediction of disease outcome and disease subtype identification).

I want to connect gene expression with cellular function.

I need to identify cellular targets for toxicology studies at an early stage.

I would like to do expression analysis of sense-antisense gene pairs and complex gene architectures.

I need to analyze expression data of non-coding RNAs, their gene targets and find clinical associations.

I have a large set of genes and would like to have them annotated automatically.

I would like to know more details on your genome and gene expression related research and applications.

My screen identified a protein of unknown function, can you find out more about its function?

I need a detailed evolutionary conservation and phylogenetics analysis.

I work with a large family of related proteins, and would like to analyze specificity determinants in each family.

I have a large set of protein sequences and would like to have them annotated automatically.

Are there any known interaction partners of my protein or its homologs?

I would like to narrow down gene/protein targets for a particular project using a bottom-up Bioinformatics approach.

I would like to know genes/proteins and pathways involved in a particular disease to screen patients for mutations.

I have a list of candidate genes/proteins and would like to know the most likely candidate for a particular disease.

I found a disease-associated non-synonymous SNP/amino acid mutation in my patients/samples and would like to know any predictable phenotypic effects and their biomolecular mechanisms.

I would like to know more details on your protein sequence related research and applications.

I would like to construct a 3D structural model of my protein.

I have a protein structure or model and would like to find functionally important sites on its surface.

I have a protein structure and would like to find related structures (including local similarity searches).

I have a protein structure and want to find potential protein interaction partners.

I need to understand the effects of drugs in different patients based on SNPs in known targets.

I need to understand the structural aspects of mutations in target proteins that lead to resistance to drugs.

I have a structural complex of a related protein with ligand and want to know if this ligand also binds to my protein.

I would like to develop an inhibitor for my protein.

I would like to re-engineer my protein for a specific task.

I would like to know more details on your protein structure related research and applications.

I have a series of clinical or cell-biological images and would need a more automated computational analysis.

I have color images of histological sections and would need a quantitative analysis of these images, such as counting cells or measuring areas of a particular color.

I need computer aided diagnosis through pathological slides of biopsy samples.

I need to automatically quantify cellular phenotypes obtained from high-content RNAi or small-molecule screenings.

I have 3D-4D image data (video, time series or 3D stack of images) and would need a more automated computational analysis?

Can bio-imaging help in clinical settings and in the patient management in the hospital?

I would like to know more details on your bio-imaging related research and applications.

I have a Bioinformatics question that is not listed here, whom can I contact?

Please contact sebastianms@bii.a-star.edu.sg