The Bioinformatics Institute (BII) is dedicated to primarily computational biology/bioinformatics driven life science research aimed at the discovery of biomolecular mechanisms guiding biological phenomena. The final goals are scientific advancement as well as economic and social impact for Singapore. Education of students and young scientists is facilitated by their active involvement in ongoing research projects supervised by international faculty. Sophisticated theoretical and computational approaches including artificial intelligence are applied to analyze all sorts of biological and clinical data, mainly omics data (biomolecular sequences, expression profiles, epigenetics data), 3D structures of macromolecules and biological as well as medical cellular, tissue and macroscopic images from local and international academic, hospital and industry collaborators, public resources and from own experiments. Applied research diversifies into infectious diseases, computational toxicology, natural product research, precision medicine, cancer research, drug discovery, etc. BII houses Singapore’s Natural Organism Library, the Natural Product Discovery Platform and the Secondary Clinical Data Sink, a clinical trial database.