18 January 2006
A*STAR scientists unravel more mysteries of p53
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The p53 gene is well recognized for its role in suppressing tumour formation, but many of its functions remain a mystery. Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) and Genome Institute of Singapore (GIS) have recently made new discoveries about the gene. They have respectively discovered that p53 is not only associated with cancer, but also plays a vital role in organ development, and developed a premium analytical method to map out the p53 target binding genes in the entire human genome. These recent discoveries shed new light on the functions of p53 and provide new biomarkers for early cancer detection as well as monitoring of therapeutic treatment. Their research findings were published in the recent issues of "Genes and Development" and "Cell", both of which are prestigious scientific journals for reporting advanced biological discoveries

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