2008
 Thu, 14 Aug 2008
Symposium on Biomolecular Mechanism Discovery with Computational Biology
Introduction
The symposium on "Biomolecular Mechanism Discovery with Computational Biology" is jointly organized by the Bioinformatics Institute, A*STAR and ProBioC, a society for the advancement ... more
Tue, 12 Aug 2008
Introduction to UV area imaging – a powerful new tool for life science research
We report on the development and applications of a novel UV area imaging detector, the ActiPix D100. The patented technology based on a 9 mm x 7 mm active pixel sensor opens up new applications for sc... more
Mon, 11 Aug 2008
Protein electrostatics
This lecture/ tutorial will cover:
• Role of electrostatic properties in protein interactions and function.
• Some computational approaches to compute the electrostatic properties of proteins and us... more
Tue, 05 Aug 2008
Choosing the right tool for the task: How to make best use of DNA expression microarray analysis
DNA expression microarray technology seems to have become ubiquitous in the decade since its inception. Two main applications are propagated: clinical diagnostics, and pathway discovery. In this lectu... more
Wed, 07 May 2008
Ingenuity Pathways Analysis (IPA): What’s New in IPA 6.0
Abstract
Ingenuity Pathways Analysis (IPA) is an all-in-one software application that helps researchers analyze their experimental data in the context of biological pathways, functions, and interacti... more
Mon, 05 May 2008
The "wet", the "dry" and viceversa: from hypothesis generation to bio-data providers
Abstract
Important biological questions require special attention from the scientific community. Bioinformatics, as part of Biology, contribute to address such questions in many different ways from h... more
Mon, 05 May 2008
RASOMICS: An integrative approach
Abstract
Ras genes code for small GTPases that act as GDP/GTP-regulated molecular switches involved in many biological pathways. Conformational changes allow them to interact with regulators and effe... more
Fri, 25 Apr 2008
Structural correlates of the temperature-sensitive phenotype
Abstract
A library consisting of ~1500 (75% of all possible) single site mutants of the 101 residue, homodimeric E. coli toxin CcdB was constructed. Mutants were characterized in terms of their activ... more
Fri, 25 Apr 2008
Quality assessment of gene annotation in low quality eukaryotic genomes
Abstract
Recent advances in sequencing technologies produced unprecedented amount of genomic sequence data. Whole genome shotgun sequencing produces increasingly higher coverage of a genome with rand... more
Fri, 04 Apr 2008
Integrative Visualization of ArrayCGH, Expression and Supplementary Variables
Abstract
The intuitive way to analyze different omics data is 'separately and consecutively'; e.g. first determine regions with copy number aberrations and then look for differentially expressed gene... more
Wed, 26 Mar 2008
Analysis of High-throughput Biological Data: Methods, Algorithms and Applications
Abstract
I will present a brief overview of some of the research carried out in my group over the past few years. Our focus is on experiments that generate massive amounts of biological data by means... more
Thu, 20 Mar 2008
Symposium on Biomolecular Structural Dynamics
Understanding mechanisms at a molecular level are being driven by rapid developments in experimental and simulation technologies, most notably in accessing events at the level of single molecules or a... more
Thu, 13 Mar 2008
Structure Function Relationship of Proteins studied by Molecular Dynamics Simulations
Abstract
Molecular Dynamics (MD) Simulation has become a powerful tool to investigate biological systems on the molecular level. With ever increasing computational power, longer simulation times and ... more
Mon, 25 Feb 2008
Lecture - The Evolution of Meiosis from Mitosis
Adam S. Wilkins and Robin Holliday
Abstract
The evolution of meiosis remains one of the most significant problems in evolutionary biology. Meiosis is essential to sexual reproduction and sexual re... more
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