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2017

Fri, 17 Feb 2017
Towards integrated modeling of animal morphogenesis by data-assimilation

Time: 10.00 AM - 11.00 AM

Venue: Cysteine, Level 7 (30 Biopolis Street, Matrix)

Speaker: Dr. Emmanuel Faure, CR2 CNRS Researcher, Institut de Recherche en Informatique de Toulouse, France

Abstract

I'm going to present a project based on multi-scale modeling of the animal morphogenesis which integrates the couple of dynamics genetic interactions and cell mechanics. The major challenge of this project is to think the models according to the biological observations and the qualitative descriptions made by the biologists at different levels of observation. In order to understand cellular behaviors during animal embryogenesis I will present several methods, from data acquisition to 4D visualisation, to reconstruct in vivo and in toto animal embryogenesis at the cell level. From this quantitative reconstruction, we have been characterized several cell specification events for the first stages of development. And the genetic approach, I will present a boolean model of Gene regulatory networks witch reproduce the control of the dynamic spatial patterns of regulatory gene expression in development.


About The Speaker
Emmanuel Faure joined the CNRS in 2015 as a researcher at the IRIT lab in Toulouse. He received his PhD from the Ecole Polytechnique in Complex Systems science in 2009. During this time, he worked in collaboration with developmental biologists, physicists and mathematicians on reconstructing the cell lineage tree of multiples organisms from 4D images datasets. He joined the Davidson Laboratory in Caltech in 2010 for a 2 years postdoctoral position working on gene regulatory network models. Back in France, as a research engineer, he was the technical director of the BioEmergences platform integrating an automatic workflow for all reconstruction steps from image acquisition and processing to the interactive visualization of reconstructed data. He coordinated the installation of a data center (clusters and storage) for France Bio Imaging national infrastructure. In 2014, he did a postdoc at the Computational Biology Institute in Montpellier, working on data assimilation.


Host
Dr. Thomas Boudier, Visiting Institute Fellow /
Dr. Lee Hwee Kuan, Head of Research Division / Snr. Principal Investigator


 
 
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