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2017

Tue, 27 Jun 2017
Discovery, mechanism of action, biosynthesis and bioengineering of antibiotics from Gram-negative bacteria

Time: 11.00 AM - 12.00 PM

Venue: Cysteine, Level 7 (30 Biopolis Street, Matrix)

Speaker: Prof. Greg Challis, Monash-Warwick Alliance Professor of Sustainable Chemistry (Chemical and Synthetic Biology), Department of Chemistry, University of Warwick, UK

Abstract

The overwhelming majority of antibiotics in clinical use are natural products or semi-synthetic derivatives produced by Gram-positive Actinobacteria and filamentous fungi. Pathogenic microorganisms are becoming increasingly resistant to these compounds, and there is thus an urgent need to discover novel antibiotics to address the emerging health threat this poses.
In contrast to Actinobacteria, the production of antibiotics by Gram-negative bacteria remains relatively underexplored. In this lecture, the discovery of antibiotics from Burkholderia and other Gram-negative bacterial genera will be described, with a particular focus on novel (and known) polyketides that have potent activity against important antibiotic-resistant pathogens such as Mycobacterium tuberculosis and Acinetobacter baumannii. The mechanisms of action of these compounds will be discussed and their biosynthetic gene clusters will be described. Efforts to understand the pathways responsible for the biosynthesis of the compounds will be reported, along with exploitation of the knowledge gained to produce novel antibiotic analogues via biosynthetic engineering. The results of these studies are delivering valuable information about structure-activity relationships that will inform future efforts to develop antibiotics with the potential to neutralise the threat posed by the current crop of multi-drug resistant pathogens.


About The Speaker
Current position: Monash-Warwick Alliance Professor of Sustainable Chemistry (Chemical and Synthetic Biology), Department of Chemistry, University of Warwick (UK) and Department of Biochemistry and Molecular Biology, Monash University (Australia)
1994 BSc in Chemistry, Imperial College London (UK)
1994-1998 DPhil in Organic Chemistry with Prof Sir Jack Baldwin, University of Oxford (UK)
1998-2000 Wellcome Trust Postdoctoral Fellow with Prof Craig Townsend, Johns Hopkins University (USA)
2000-2001 Wellcome Trust Postdoctoral Fellow with Prof Keith Chater, John Innes Centre (UK)
2001-2006 Lecturer, Senior Lecturer, Reader in Chemical Biology, Department of Chemistry, University of Warwick (UK)
2006-2016 Professor of Chemical Biology, Department of Chemistry, University of Warwick (UK)
Research Interests: Discovery, biosynthesis, bioengineering and mechanism of action of antibiotics and other bioactive natural products


Host
Dr. Hao Fan / Principal Investigator



 
 
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