Mon, 12 Dec 2016
CUBIC: A platform for cell-omics analysis toward organism-level systems biology
A multicellular organism is composed of various types of cells inside, where they connect with each other and work in a coordinated manner. The regulatory mechanism of an organism-level biological fun... more

  Fri, 18 Nov 2016
Influenza virus evolution, from protein to population
Influenza viruses have the remarkable ability to infect us multiple times over the course of our lives due to the evolution of their surface proteins and consequent ability to escape prior immunity. A... more

  Fri, 21 Oct 2016
A Nature editor's view of bioengineering
An overview of some recent trends in bioengineering in biomedicine and beyond. Which areas are we following and which areas are we seeing most papers being submitted. Some statistics on submissions at... more

  Tue, 04 Oct 2016
Extending the reach of target discovery for cancer and other diseases
Cellular pathways are controlled by interactions between biological macromolecules, which may be perturbed by disease-associated changes in the concentration, localization or structure of the reactant... more

  Mon, 19 Sep 2016
Distinguishing allostery from orthosteric binding in protein-ligand interactions by mass spectrometry
The inherent dynamic ability of proteins to exist in ensembles of multiple conformations not unlike "molecular springs" in solution, is a prerequisite for function. An understanding of protein dynamic... more

  Tue, 23 Aug 2016
Topological modeling and analysis of complex data in biomolecules
The understanding of biomolecular structure, flexibility, function, and dynamics is one of the most challenging tasks in biological science. We have introduced flexibility and rigidity index (FRI) for... more

  Thu, 18 Aug 2016
Bioinformatics Mining and Modeling Methods for the Identification of Disease Mechanisms in Neurodegenerative Disorders
Since the decoding of the Human Genome, techniques from bioinformatics, statistics, and machine learning have been instrumental in uncovering patterns in increasing amounts and types of different data... more

  Mon, 18 Jul 2016
Learning and Designing Covariance-matrix-based Representation for Visual Recognition
During the past several years, covariance matrices have been used as feature representation in multiple visual recognition tasks. This talk will report our recent work on learning and designing covari... more

  Thu, 16 Jun 2016
Multiscale structures and dynamics of proteins: folding, self-assembly, and network formation via a coarse-grained approach
Understanding the structure and dynamics of a protein remain an open problem despite enormous efforts in the last few decades with various computational approaches. A number of issues are involved in ... more

  Fri, 29 Apr 2016
Structural Basis for Immune Recognition of Intrinsically Disordered Vaccine Candidates
Intrinsically disordered proteins are highly abundant in pathogenic organisms. Our bioinformatic analyses show that disordered antigens can be very effective antigens. Little is known, however, about ... more

  Thu, 14 Apr 2016
Unzipping Diploid Genomes with PacBio Continuous Long Reads: From Contigs to "Haplotigs"
Outside of the simplest cases (haploid, bacteria, or inbreds), genomic information is not carried in a single reference per individual, but rather has higher ploidy (n ≥ 2) for almost all organisms... more

  Tue, 05 Apr 2016
Protein Lipidation as a Target for Drug Discovery in Malaria
Resistance has undermined the use of chloroquine and anti-folates in malaria treatment and is threatening the future use of current front line therapies based on artemisinin combination therapy. This ... more

  Fri, 11 Mar 2016
Modelling multi-component membranes to understand its shape
I will present a summary of our recent investigations on the influence that membrane protein interactions and the lipid compositions of membranes have on the membrane conformation. Investigations usin... more

  Fri, 04 Mar 2016
An in silico insight into the mechanism of Endogenous Retroviral Silencing
Endogenous retroviruses (ERVs) are viral elements that were incorporated into mammalian genomes millions of years ago. Expression of some of these viral elements can lead to deleterious effects on the... more

  Wed, 24 Feb 2016
Is it a time for nanopore sequencing?
Nanopore sequencing device are getting popular. Their portable design makes them promising for in-field surveillance applications. The number of publications in high-profile journals is growing. Is th... more

  Fri, 19 Feb 2016
Design of new multi-target drugs: Case studies with neuroprotective and anti-inflammatory agents
In the last two decades, drug discovery has focused mainly on single-target approach ('one disease - one target'). This strategy has however failed in many cases; in fact, no disease-modifying agents ... more

  Thu, 28 Jan 2016
Protein evolution in steps and leaps
In classical models of protein evolution, homologous proteins have diverged by accumulation of small changes of their amino acid sequences. A large body of empirical evidence suggests that structural ... more

  Wed, 27 Jan 2016
D. E. Shaw Research Information Session
D. E. Shaw Research is an independent research laboratory that conducts basic scientific research in the field of computational biochemistry under the direct scientific leadership of Dr. David E. Shaw... more