Wed, 06 Dec 2017
Multiple roles of the alphavirus nsP3 protein in modulation of cellular responses to infection
Alphaviruses including chikungunya virus, Ross River virus and the model Semliki Forest virus are enveloped viruses with a single-stranded, positive sense RNA genome, that are transmitted to humans an... more

  Fri, 24 Nov 2017
Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets
Intrinsically disordered proteins (IDPs) play key roles in signaling and regulation. Many IDPs undergo folding upon binding to their targets. We have proposed that coupled folding and binding of IDPs ... more

  Thu, 16 Nov 2017
Protein transport into peroxisomes: The peroxisomal targeting signal type-2 is recognized by a bipartite receptor complex
In eukaryotic cells the compartmentation of proteins into membrane bound compartments requires active transport processes. This transport depends on the interaction between a targeting signal encoded ... more

  Wed, 15 Nov 2017
Computational studies of biomolecular stability and interactions
Adaptive mutations that alter the functionality of proteins are enriched within intrinsically disordered protein regions (IDRs), thus conformational flexibility appears to translate to evolvability. P... more

  Tue, 14 Nov 2017
Principles Governing Biological Processes: Applications to drug design and drug target
Our research is centered upon elucidating the key physicochemical principles underlying complex biological systems, notably those governing interactions between inorganic or organic cofactors and biom... more

  Tue, 14 Nov 2017
Molecular interactions in gene-regulating RNAs and DNAs
Ribonucleic acid (RNA) molecules can regulate gene expression. In bacteria, natural riboswitches, occurring within the untranslated region of messenger RNA, regulate gene expression after binding with... more

  Tue, 27 Jun 2017
Discovery, mechanism of action, biosynthesis and bioengineering of antibiotics from Gram-negative bacteria
The overwhelming majority of antibiotics in clinical use are natural products or semi-synthetic derivatives produced by Gram-positive Actinobacteria and filamentous fungi. Pathogenic microorganisms ar... more

  Mon, 19 Jun 2017
Interdisciplinary computing and complex Biosystems research at Newcastle University
Over the past 40 years technological developments in biology and medicine and the concurrent developments in computing technology means that informatics now plays an essential role in the life science... more

  Thu, 01 Jun 2017
Uncovering unknown functions of Ca2+-binding proteins in chloroplast development and signaling
Calcium is an important secondary messenger in animal and plant signalling and in plant cells chloroplasts are able to store large amounts of calcium. However, not much is known about the role of calc... more

  Thu, 27 Apr 2017
How to feel safe... or which infectious diseases are really going to kill you
Infectious diseases have the potential to ravage human populations. However, in modern high-income countries, the threat from the majority of diseases that plagued people in recent centuries has been ... more

  Tue, 07 Mar 2017
Haze and decision making: A natural laboratory experiment
The adverse impact of haze on health and related socioeconomic outcomes has received increasing attention in the media. Recent biological studies point to a short-term impact of haze on brain function... more

  Fri, 17 Feb 2017
Towards integrated modeling of animal morphogenesis by data-assimilation
I'm going to present a project based on multi-scale modeling of the animal morphogenesis which integrates the couple of dynamics genetic interactions and cell mechanics. The major challenge of this pr... more

  Mon, 23 Jan 2017
Seminar (2) : From Salvarsan to Penicillin: Was Fleming a genius, a lucky guy, or neither?
Many important scientific discoveries are attributed to an unusual and fortuitous serendipity. Careful analysis of such cases, however, reveals luck to be just one parameter, not necessarily the most ... more

  Mon, 23 Jan 2017
Seminar (1) : The birth of the discipline of biochemistry - Why did it wait to the 20th century?
The 1907 Nobel Prize for Chemistry, awarded to Eduard Buchner, marked the recognition of the scientific community in the discipline, then in its infancy, known as biochemistry. By that time, other bio... more