Loo Lit Hsin

Senior Principal Investigator
   Research Group: Complex Cellular Phenotype Analysis

Loo Lit Hsin is a Principal Investigator at the Bioinformatics Institute (BII), A*STAR, Singapore. He is leading an interdisciplinary team of scientists developing in vitro and computational models for predicting the toxicity and/or targets of chemical compounds with diverse or unknown structures. His team has developed novel imaging-based phenotypic profiling methods and tools that led to the first high-throughput and predictive in vitro platform for nephrotoxicity prediction. Dr. Loo is also an adjunct Assistant Professor at the Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. He was the recipient of the Lush Prize – Science Award (2016), Award for Excellence in Postdoctoral Research (2010) and the Alfred Gilman Award (2009) by the University of Texas Southwestern (UTSW) Medical Center, and the Doctoral Award in Mathematical Sciences and Engineering (2005) by Drexel University. Dr. Loo was a postdoctoral fellow in the Bauer Center for Genomics Research at Harvard University (2005), and then in the Department of Pharmacology at the UTSW Medical Center, USA (2005-2010).

Dr. Loo’s background is in computational and systems biology. His team has previously developed novel high-throughput imaging-based phenotypic profiling (HIPPTox) methods that led to highly predictive in vitro assays for kidney and lung toxicities. Under the IFCS Programme, he is responsible to integrate various unique molecular and phenotypic profiling technologies developed in multiple A*STAR research institutes into a single platform, called the ToxMAD Platform, for elucidating the targets and modes of action of chemicals. Dr. Loo is also leading A*STAR’s participations in the International Workgroup on Accelerating the Pace of Chemical Risk Assessments (APRCA) and the associated Point-of-Departure case study.

Complex Cellular Phenotype Analysis Members

Dr. LOO Lit Hsin
Principal Investigator
  Biography Details
  Lab Website
Dr. LOO Lit HsinPrincipal Investigator
Dr. MILLER James AlastairPost-Doctoral Research Fellow
Dr. BASU SreetamaPost-Doctoral Research Fellow
Dr. HTWE Su SuPost-Doctoral Research Fellow
Ms. LEE Jia Ying JoeySenior Research Officer
Ms. KONG Jia WenResearch Officer
Mr. FU Shufeng OscarResearch Officer
Mr. CAIN Paul EdwardSoftware Engineer
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