Biochemistry Group
 
Dr. Sharmila ADHIKARI
Principal Investigator

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Research Overview

This is a protein biochemistry/molecular biology group involved in the verification of sequence-analytic hypotheses to identify functional regions of proteins and for the generation of experimental data that can be used for the development of new prediction tools. With a set of standardized assays (enzymology, post-translational modifications, identification of protein substrates of enzymes/receptors/ transporters, etc.), our biochemical lab aims to bridge the gap between theoretical predictions on the one hand, and cell biology and genetics research on the other. What is truly unique about the group is our integrated approach. Scientists from multiple disciplines (molecular biology, genetics, biochemistry and bioinformatics) work closely together to fully understand different aspects of the inherently complex systems intrinsic to living organisms.
 
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Selected Publications
 
  1. Eisenhaber B, Sammer M, Lua WH, Benetka W, Liew LL, Yu W, Lee HK, Koranda M, Eisenhaber F, Adhikari S.
    Nuclear import of a lipid-modified transcription factor: Mobilization of NFAT5 isoform a by osmotic stress.
    Cell Cycle. 2011 Nov 15;10(22). [Epub ahead of print]
    PMID: 22071693


  2. Kamariah N, Eisenhaber F, Adhikari S, Eisenhaber B, Grüber G.
    Purification and crystallization of yeast glycosylphosphatidylinositol transamidase subunit PIG-S (PIG-S(71-467)).
    Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):896-9. Epub 2011 Jul 19.
    PMID: 21821889


  3. Toh YK, Kamariah N, Maurer-Stroh S, Roessle M, Eisenhaber F, Adhikari S, Eisenhaber B, Grüber G.
    Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast.
    J Struct Biol. 2010 Dec 4. [Epub ahead of print]
    PMID: 21134462


  4. Limviphuvadh V, Chua LL, Adawiyah Bte Rahim RA, Eisenhaber F, Maurer-Stroh S, Adhikari S.
    Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2.
    BMC Biochem. 2010 Sep 24;11(1):39.
    PMID: 20863412


  5. Limviphuvadh V, Chua LL, Eisenhaber F, Adhikari S, Maurer-Stroh S.
    Is LGI2 the candidate gene for partial epilepsy with pericentral spikes?
    J Bioinform Comput Biol. 2010 Feb;8(1):117-27.
    PMID: 20183877


 
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