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Biochemistry Group
"Exploring the Impact of Post-translational Lipid Modifications on Life" |
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Research Overview
This is a protein biochemistry/molecular biology group involved in the verification of sequence-analytic hypotheses to identify functional regions of proteins and for the generation of experimental data that can be used for the development of new prediction tools. With a set of standardized assays (enzymology, post-translational modifications, identification of protein substrates of enzymes/receptors/ transporters, etc.), our biochemical lab aims to bridge the gap between theoretical predictions on the one hand, and cell biology and genetics research on the other. What is truly unique about the group is our integrated approach. Scientists from multiple disciplines (molecular biology, genetics, biochemistry and bioinformatics) work closely together to fully understand different aspects of the inherently complex systems intrinsic to living organisms.
Research Objectives
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Signal Transduction & Transcriptional Regulation
We found a new mechanism of regulating nuclear shuttling of transcription factors via post-translational lipid modifications. To further extend this project we will focus on the molecular mechanism and biological impact of different splice variants with and without lipid modifications on transcriptional regulation. |
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Parasite-Host Interactions
This project focuses on the role of post-translational lipid modifications of parasite proteins of human pathogens in evasion of intracellular host defense. The knowledge gained would help us to identify new drug targets and also shed light on the evolution of host-parasite interaction. |
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Asymmetric Cell Division
The goal of the project is to investigate the regulatory and functional role of post-translational lipid modifications on a Ser/Thr kinase family member in D. melanogaster. This will help us to gain insight into basic mechanisms of embryonic development and cell fate determination. |
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