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Dr. Frank EISENHABER
Principal Investigator
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Dr. Sebastian MAURER-STROH
Principal Investigator
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| Group Members |
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| Name | Title |
| Dr. Frank EISENHABER |
Principal Investigator |
| Dr. Sebastian MAURER-STROH |
Principal Investigator |
| Dr. CHEN Li |
Postdoctoral Fellow |
| Dr. LOW Wee Chuang |
Postdoctoral Fellow |
| Dr. MA Jianmin |
Postdoctoral Fellow |
| Dr. Vachiranee LIMVIPHUVADH |
Postdoctoral Fellow |
| Mr. HAN Hao |
Research Associate |
| Mr. LEE Tze Chuen |
Research Associate |
| Mr. TAN Tang Sheng Joshua |
Research Associate |
| Mr. WONG Wing Cheong |
Research Associate |
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Research Overview
Although the complete sequencing of the human and other genomes was almost a decade ago, we find ourselves in the exciting situation that still only a subset of the identified genes is functionally well characterized. Our group embarks on the journey to map the functions of the many remaining uncharacterized genes, and the proteins they are translated to. Furthermore, it is not sufficient to look at the individual components of complex biological systems but rather consider the context of their interaction with each other to better understand how our cells, organs and bodies work.
Based primarily on protein sequence analysis and the analysis of other sequence-associated data, the various aspects of molecular and cellular function (enzymatic activities, posttranslational modifications, cleavage, translocation signals, 3D structures, pathway relationships, etc.) are predicted.
Our work is strongly facilitated by the ANNOTATOR group which provides a software service for efficient sequence-analytic workflows. Finally, the hypotheses about protein functions are either followed up by experimental collaborators or they are validated in the Division's own protein biochemical laboratory.
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| More Details |
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| Selected Publications |
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- Sleegers K, Brouwers N, Maurer-Stroh S, van Es MA, Van Damme P, van Vught PW, van der Zee J, Serneels S, De Pooter T, Van den Broeck M, Cruts M, Schymkowitz J, De Jonghe P, Rousseau F, van den Berg LH, Robberecht W, Van Broeckhoven C.
Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
Neurology. 2008 Jan 9; [Epub ahead of print]
PMID: 18184915 [PubMed - as supplied by publisher]
- Eisenhaber B, Eisenhaber F.
Posttranslational modifications and subcellular localization signals: indicators of sequence regions without inherent 3D structure?
Curr Protein Pept Sci. 2007 Apr;8(2):197-203. Review.
PMID: 17430201 [PubMed - indexed for MEDLINE]
- Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.
Towards complete sets of farnesylated and geranylgeranylated proteins.
PLoS Comput Biol. 2007 Apr 6;3(4):e66. Epub 2007 Feb 23.
PMID: 17411337 [PubMed - indexed for MEDLINE]
- Eisenhaber B, Chumak N, Eisenhaber F, Hauser MT.
The ring between ring fingers (RBR) protein family.
Genome Biol. 2007;8(3):209. Review.
PMID: 17367545 [PubMed - indexed for MEDLINE]
- Eisenhaber F (editor)
Discovering Biomolecular Mechanisms with Computational Biology.
Landes Bioscience and Springer (publisher), New York, 2006
ISBN: 978-0-387-34527-7
- Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM.
The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.
Mol Cell. 2005 May 27;18(5):543-53.
PMID: 15916961 [PubMed - indexed for MEDLINE]
- Maurer-Stroh S, Eisenhaber F.
Refinement and prediction of protein prenylation motifs.
Genome Biol. 2005;6(6):R55. Epub 2005 May 27.
PMID: 15960807 [PubMed - indexed for MEDLINE]
- Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R.
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Science. 2004 Nov 19;306(5700):1383-6.
PMID: 15550674 [PubMed - indexed for MEDLINE]
- Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP.
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
Trends Biochem Sci. 2003 Feb;28(2):69-74.
PMID: 12575993 [PubMed - indexed for MEDLINE]
- Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T.
Regulation of chromatin structure by site-specific histone H3 methyltransferases.
Nature. 2000 Aug 10;406(6796):593-9.
PMID: 10949293 [PubMed - indexed for MEDLINE]
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