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Dr. Frank EISENHABER
Principal Investigator
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Dr. Sebastian MAURER-STROH
Principal Investigator
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| Group Members |
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| Name | Title |
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| Dr. EISENHABER Frank | Principal Investigator |
| Dr. MAURER-STROH Sebastian | Principal Investigator |
| Dr. KENANOV Dimitar | Postdoctoral Fellow |
| Dr. LIMVIPHUVADH Vachiranee | Postdoctoral Fellow |
| Dr. MA Jianmin | Postdoctoral Fellow |
| Dr. VITHIAGARAN Gunalan | Postdoctoral Fellow |
| Mr. HAN Hao | Research Associate |
| Mr. LEE Tze Chuen | Research Officer |
| Mr. NEO Keng Hwee | Research Officer |
| Mr. WONG Wing Cheong | Research Officer |
| Ms. XIANG Shengnan Joy | Research Officer |
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Research Overview
Although the complete sequencing of the human and other genomes was almost a decade ago, we find ourselves in the exciting situation that still only a subset of the identified genes is functionally well characterized. Our group embarks on the journey to map the functions of the many remaining uncharacterized genes, and the proteins they are translated to. Furthermore, it is not sufficient to look at the individual components of complex biological systems but rather consider the context of their interaction with each other to better understand how our cells, organs and bodies work.
Based primarily on protein sequence analysis and the analysis of other sequence-associated data, the various aspects of molecular and cellular function (enzymatic activities, posttranslational modifications, cleavage, translocation signals, 3D structures, pathway relationships, etc.) are predicted.
Our work is strongly facilitated by the ANNOTATOR group which provides a software service for efficient sequence-analytic workflows. Finally, the hypotheses about protein functions are either followed up by experimental collaborators or they are validated in the Division's own protein biochemical laboratory.
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| More Details |
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| Selected Publications |
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- Hurt A, Lee R, Leang S, Cui L, Deng Y, Phuah S, Caldwell N, Freeman K, Komadina N, Smith D, Speers D, Kelso A, Lin R, Maurer-Stroh S, Barr I.
Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation.
2011 Jun 9;16(23). pii: 19884.
PubMed PMID: 21679678.
- Wong WC, Maurer-Stroh S, Eisenhaber F.
The Janus-faced E-values of HMMER2: extreme value distribution or logistic function?
J Bioinform Comput Biol. 2011 Feb;9(1):179-206.
PubMed PMID: 21328712.
- Toh YK, Kamariah N, Maurer-Stroh S, Roessle M, Eisenhaber F, Adhikari S, Eisenhaber B, Grüber G.
Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast.
J Struct Biol. 2011 Feb;173(2):271-81. Epub 2010 Dec 4.
PubMed PMID: 21134462.
- Lee RT, Santos CL, de Paiva TM, Cui L, Sirota FL, Eisenhaber F, Maurer-Stroh S.
All that glitters is not gold--founder effects complicate associations of flu mutations to disease severity.
Virol J. 2010 Nov 1;7:297.
PubMed PMID: 21040570; PubMed Central PMCID: PMC2989967.
- Inoue M, Barkham T, Leo YS, Chan KP, Chow A, Wong CW, Tze Chuen Lee R, Maurer-Stroh S, Lin R, Lin C.
Emergence of oseltamivir-resistant pandemic (H1N1) 2009 virus within 48 hours.
Emerg Infect Dis. 2010 Oct;16(10):1633-6.
PubMed PMID: 20875299.
- Limviphuvadh V, Chua LL, Rahim RA, Eisenhaber F, Maurer-Stroh S, Adhikari S.
Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2.
BMC Biochem. 2010 Sep 24;11:39.
PubMed PMID: 20863412. PubMed Central PMCID: PMC2949613.
- Wong WC, Maurer-Stroh S, Eisenhaber F.
More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology.
PLoS Comput Biol. 2010 Jul 29;6(7):e1000867.
PubMed PMID: 20686689; PubMed Central PMCID: PMC2912341.
- Maurer-Stroh S, Ma J, Lee RT, Sirota FL, Eisenhaber F.
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites.
Biol Direct. 2009 May 20;4:18; discussion 18.
PubMed PMID: 19457254; PubMed Central PMCID: PMC2691737.
- Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R.
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Science. 2004 Nov 19;306(5700):1383-6.
PMID: 15550674
- Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T.
Regulation of chromatin structure by site-specific histone H3 methyltransferases.
Nature. 2000 Aug 10;406(6796):593-9.
PMID: 10949293
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