Protein Sequence Analysis Group
 
Dr. MAURER-STROH Sebastian
Senior Principal Investigator

Details
 
 
 
Group Members
 
NameTitle
Dr. MAURER-STROH SebastianPrincipal Investigator
Dr. LIMVIPHUVADH VachiraneeResearch Scientist
Dr. KENANOV Dimitar Postdoctoral Fellow
Dr. TAN Soon Heng, ChrisPostdoctoral Fellow
Dr. VITHIAGARAN GunalanPostdoctoral Fellow
Dr. NISKA JoannaPostdoctoral Fellow
Mr. LEE Tze ChuenResearch Officer
Mr. HAN Xiaochuan Alvin PhD student
Mr. CHONG Cheng Shoong, Ken PhD student
 
Research Overview

Our expertise is in computational protein sequence and structure analysis to predict various aspects of molecular and cellular functions (enzymatic activities, posttranslational modifications, cleavage, translocation signals, 3D structures, effects of mutations, phylogenetic relationships, cellular pathways etc.) for discovering the molecular mechanisms of biological and clinical phenotypes and experimental validation together with collaborators. Our repertoire of computational analysis methods is applicable and useful in multiple research areas but our main focus currently is on infectious diseases, allergy and human mutations.
 
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Selected Publications
 
  1. Lackenby A, Besselaar TG, Daniels RS, Fry A, Gregory V, Gubareva LV, Huang W, Hurt AC, Leang SK, Lee RTC, Lo J, Lollis L, Maurer-Stroh S, Odagiri T, Pereyaslov D, Takashita E, Wang D, Zhang W, Meijier A.
    Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals.
    Antiviral Res. 2018 Sep;157:38-46. doi: 10.1016/j.antiviral.2018.07.001. Epub 2018 Jul 3.
    PubMed PMID: 29981793


  2. Limviphuvadh V, Tan CS, Konishi F, Jenjaroenpun P, Xiang JS, Kremenska Y, Mu YS, Syn N, Lee SC, Soo RA, Eisenhaber F, Maurer-Stroh S, Yong WP.
    Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy.
    BMC Cancer. 2018 May 11;18(1):555. doi: 10.1186/s12885-018-4471-x.
    PubMed PMID: 29751792; PubMed Central PMCID: PMC5948914


  3. Taye B, Vaz C, Tanavde V, Kuznetsov VA, Eisenhaber F, Sugrue RJ, Maurer-Stroh S.
    Benchmarking selected computational gene network growing tools in context of virus-host interactions.
    Sci Rep. 2017 Jul 19;7(1):5805. doi: 10.1038/s41598-017-06020-6.
    PubMed PMID: 28724991; PMCID: PMC5517527


  4. Ho ZJM, Hapuarachchi HC, Barkham T, Chow A, Ng LC, Lee JMV, Leo YS, Prem K, Lim YHG, de Sessions PF, Rabaa MA, Chong CS, Tan CH, Rajarethinam J, Tan J, Anderson DE, Ong X, Cook AR, Chong CY, Hsu LY, Yap G, Lai YL, Chawla T, Pan L, Sim S, Chen IM, Thoon KC, Yung CF, Li JH, Ng HLD, Nandar K, Ooi PL, Lin RTP, Aw P, Uehara A, Pratim De P, Soon W, Hibberd ML, Ng HH, Maurer-Stroh S, Sessions OM..
    Outbreak of Zika virus infection in Singapore: an epidemiological, entomological, virological, and clinical analysis.
    Lancet Infect Dis. 2017 Aug;17(8):813-821. doi: 10.1016/S1473-3099(17)30249-9. Epub 2017 May 17.
    PubMed PMID: 28527892.


  5. Lipsitch M, Barclay W, Raman R, Russell CJ, Belser JA, Cobey S, Kasson PM, Lloyd-Smith JO, Maurer-Stroh S, Riley S, Beauchemin CA, Bedford T, Friedrich TC, Handel A, Herfst S, Murcia PR, Roche B, Wilke CO, Russell CA.
    Viral factors in influenza pandemic risk assessment.
    Elife. 2016 Nov 11;5. pii: e18491. doi: 10.7554/eLife.18491.
    PubMed PMID: 27834632; PubMed Central PMCID: PMC5156527


  6. Maurer-Stroh S, Mak TM, Ng YK, Phuah SP, Huber RG, Marzinek JK, Holdbrook DA, Lee RT, Cui L, Lin RT..
    South-east Asian Zika virus strain linked to cluster of cases in Singapore, August 2016.
    Euro Surveil. 2016 Sep 22;21(38). doi: 10.2807/1560-7917.ES.2016.21.38.30347..
    PubMed PMID: 27684526; PubMed Central PMCID: PMC5073200


  7. Wee KB, Lee RT, Lin J, Pramono ZA, Maurer-Stroh S.
    Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance.
    PLoS Comput Biol. 2016 Jan 15;12(1):e1004663. doi: 10.1371/journal.pcbi.1004663. eCollection 2016 Jan.
    PubMed PMID: 26771381; PubMed Central PMCID: PMC4714944


  8. Ponomarenko J, Vaughan K, Sette A, Maurer-Stroh S.
    Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks.
    PLoS Curr. 2014 Nov 3;6. pii: ecurrents.outbreaks.f1a7028a13ce1c5f0bdbb4b0cc0b919b. doi: 10.1371/currents.outbreaks.f1a7028a13ce1c5f0bdbb4b0cc0b919b.
    PubMed PMID: 25642381 ; PubMed Central PMCID: PMC4234462


  9. Vijaykrishna D, Holmes EC, Joseph U, Fourment M, Su YC, Halpin R, Lee RT, Deng YM, Gunalan V, Lin X, Stockwell TB, Fedorova NB, Zhou B, Spirason N, Kühnert D, Bošková V, Stadler T, Costa AM, Dwyer DE, Huang QS, Jennings LC, Rawlinson W, Sullivan SG, Hurt AC, Maurer-Stroh S, Wentworth DE, Smith GJ, Barr IG.
    The contrasting phylodynamics of human influenza B viruses.
    Elife. 2015 Jan 16;4:e05055. doi: 10.7554/eLife.05055.
    PubMed PMID: 25594904 ; PubMed Central PMCID: PMC4383373


  10. Thi TH, Wang L, Ye N, Zhang J, Maurer-Stroh S, Cheng L.
    Recognizing flu-like symptoms from videos.
    BMC Bioinformatics. 2014 Sep 12;15:300. doi: 10.1186/1471-2105-15-300.
    PubMed PMID: 25217118 ; PubMed Central PMCID: PMC4180141


  11. Maurer-Stroh S, Li Y, Bastien N, Gunalan V, Lee RT, Eisenhaber F, Booth TF.
    Potential human adaptation mutation of influenza A(H5N1) virus, Canada.
    Emerg Infect Dis. 2014 Sep;20(9):1580-2. doi: 10.3201/eid2009.140240.
    PubMed PMID: 25153690 ; PubMed Central PMCID: PMC4178386


  12. Low JG, Lee LS, Ooi EE, Ethirajulu K, Yeo P, Matter A, Connolly JE, Skibinski DA, Saudan P, Bachmann M, Hanson BJ, Lu Q, Maurer-Stroh S, Lim S, Novotny-Diermayr V.
    Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers.
    Vaccine. 2014 Sep 3;32(39):5041-8. doi: 10.1016/j.vaccine.2014.07.011. Epub 2014 Jul 18.
    PubMed PMID: 25045806.


  13. Ma J, Eisenhaber F, Maurer-Stroh S.
    Automatic phylogenetic classification of bacterial Beta-lactamase sequences including structural and antibiotic substrate preference information.
    J Bioinform Comput Biol. 2013 Dec;11(6):1343011. doi: 10.1142/S0219720013430117. Epub 2013 Dec 11.
    PubMed PMID: 24372040.


  14. Maurer-Stroh S, Gunalan V, Wong WC, Eisenhaber F.
    A simple shortcut to unsupervised alignment-free phylogenetic genome groupings, even from unassembled sequencing reads.
    J Bioinform Comput Biol. 2013 Dec;11(6):1343005. doi: 10.1142/S0219720013430051. Epub 2013 Dec 2.
    PubMed PMID: 24372034.


  15. Joshi A, Lee RT, Mohl J, Sedano M, Xin KW, Tek NO, Maurer-Stroh S, Garg H.
    Genetic Signatures of HIV-1 Envelope Mediated Bystander Apoptosis.
    J Biol Chem. 2013 Nov 21. [Epub ahead of print]
    PubMed PMID: 24265318.


  16. Lee RT, Gunalan V, Van TD, Le LT, Eisenhaber F, Maurer-Stroh S.
    A new piece in the puzzle of the novel avian-origin influenza a (H7N9) virus.
    Biol Direct. 2013 Oct 26;8(1):26. [Epub ahead of print]
    PubMed PMID: 24160334.


  17. Plasman K, Maurer-Stroh S, Ahmad J, Hao H, Kaiserman D, Sirota FL, Jonckheere V, Bird PI, Gevaert K, Van Damme P.
    Conservation of the extended substrate specificity profiles among homologous granzymes across species.
    Mol Cell Proteomics. 2013 Oct;12(10):2921-34. doi: 10.1074/mcp.M113.028670. Epub 2013 Jun 20.
    PubMed PMID: 23788529; PubMed Central PMCID: PMC3790301.


  18. Guarnaccia T, Carolan LA, Maurer-Stroh S, Lee RT, Job E, Reading PC, Petrie S, McCaw JM, McVernon J, Hurt AC, Kelso A, Mosse J, Barr IG, Laurie KL.
    Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model.
    PLoS Pathog. 2013;9(5):e1003354. doi: 10.1371/journal.ppat.1003354. Epub 2013 May 9.
    PubMed PMID: 23671418; PubMed Central PMCID: PMC3649996.


  19. Tran-Viet KN, Powell C, Barathi VA, Klemm T, Maurer-Stroh S, Limviphuvadh V, Soler V, Ho C, Yanovitch T, Schneider G, Li YJ, Nading E, Metlapally R, Saw SM, Goh L, Rozen S, Young TL.
    Mutations in SCO2 are associated with autosomal-dominant high-grade myopia.
    Am J Hum Genet. 2013 May 2;92(5):820-6. doi: 10.1016/j.ajhg.2013.04.005.
    PubMed PMID: 23643385; PubMed Central PMCID: PMC3644634.


  20. Maurer-Stroh S, Lee RT, Gunalan V, Eisenhaber F.
    The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA.
    Virol J. 2013 May 1;10:139. doi: 10.1186/1743-422X-10-139.
    PubMed PMID: 23635025; PubMed Central PMCID: PMC3673898.


  21. Wong WC, Maurer-Stroh S, Schneider G, Eisenhaber F.
    Transmembrane helix: simple or complex.
    Nucleic Acids Res. 2012 Jul;40(Web Server issue):W370-5. doi: 10.1093/nar/gks379. Epub 2012 May 7.
    PubMed PMID: 22564899; PubMed Central PMCID: PMC3394259.


  22. Hurt AC, Hardie K, Wilson NJ, Deng YM, Osbourn M, Leang SK, Lee RT, Iannello P, Gehrig N, Shaw R, Wark P, Caldwell N, Givney RC, Xue L, Maurer-Stroh S, Dwyer DE, Wang B, Smith DW, Levy A, Booy R, Dixit R, Merritt T, Kelso A, Dalton C, Durrheim D, Barr IG.
    Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia.
    J Infect Dis. 2012 Jul 15;206(2):148-57. doi: 10.1093/infdis/jis337. Epub 2012 May 4.
    PubMed PMID: 22561367; PubMed Central PMCID: PMC3379839.


  23. Tan J, Kuchibhatla D, Sirota FL, Sherman WA, Gattermayer T, Kwoh CY, Eisenhaber F, Schneider G, Maurer-Stroh S.
    Tachyon search speeds up retrieval of similar sequences by several orders of magnitude.
    Bioinformatics. 2012 Jun 15;28(12):1645-6. doi: 10.1093/bioinformatics/bts197. Epub 2012 Apr 23.
    PubMed PMID: 22531216; PubMed Central PMCID: PMC3371831.


  24. Maurer-Stroh S, Debulpaep M, Kuemmerer N, Lopez de la Paz M, Martins IC, Reumers J, Morris KL, Copland A, Serpell L, Serrano L, Schymkowitz JW, Rousseau F.
    Exploring the sequence determinants of amyloid structure using position-specific scoring matrices.
    Nat Methods. 2010 Mar;7(3):237-42. doi: 10.1038/nmeth.1432. Epub 2010 Feb 14.
    PubMed PMID: 20154676.


  25. Maurer-Stroh S, Eisenhaber F.
    Refinement and prediction of protein prenylation motifs.
    Genome Biol. 2005;6(6):R55. Epub 2005 May 27.
    PubMed PMID: 15960807; PubMed Central PMCID: PMC1175975.


  26. Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP.
    The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
    Trends Biochem Sci. 2003 Feb;28(2):69-74.
    PubMed PMID: 12575993.
 
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