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Dr. Frank EISENHABER
Principal Investigator
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Dr. Sebastian MAURER-STROH
Principal Investigator
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| Group Members |
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| Name | Title |
| Dr. EISENHABER Frank |
Principal Investigator |
| Dr. MAURER-STROH Sebastian |
Principal Investigator |
| Dr. CHEN Li |
Postdoctoral Fellow |
| Dr. LIMVIPHUVADH Vachiranee |
Postdoctoral Fellow |
| Dr. MA Jianmin |
Postdoctoral Fellow |
| Mr. KENANOV Dimitar |
Postdoctoral Fellow |
| Mr. HAN Hao |
Research Associate |
| Mr. LEE Tze Chuen |
Research Officer |
| Mr. NEO Keng Hwee |
Research Officer |
| Mr. WONG Wing Cheong |
Research Officer |
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Research Overview
Although the complete sequencing of the human and other genomes was almost a decade ago, we find ourselves in the exciting situation that still only a subset of the identified genes is functionally well characterized. Our group embarks on the journey to map the functions of the many remaining uncharacterized genes, and the proteins they are translated to. Furthermore, it is not sufficient to look at the individual components of complex biological systems but rather consider the context of their interaction with each other to better understand how our cells, organs and bodies work.
Based primarily on protein sequence analysis and the analysis of other sequence-associated data, the various aspects of molecular and cellular function (enzymatic activities, posttranslational modifications, cleavage, translocation signals, 3D structures, pathway relationships, etc.) are predicted.
Our work is strongly facilitated by the ANNOTATOR group which provides a software service for efficient sequence-analytic workflows. Finally, the hypotheses about protein functions are either followed up by experimental collaborators or they are validated in the Division's own protein biochemical laboratory.
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| More Details |
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| Selected Publications |
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- Maurer-Stroh S, Ma J, Lee RT, Sirota FL, Eisenhaber F.
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites.
Biol Direct. 2009 May 20;4(1):18.
PMID: 19457254
- Van Damme P, Maurer-Stroh S, Plasman K, Van Durme J, Colaert N, Timmerman E, De Bock PJ, Goethals M, Rousseau F, Schymkowitz J, Vandekerckhove J, Gevaert K.
Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs.
Mol Cell Proteomics. 2009 Feb;8(2):258-72.
PMID: 18836177
- Benetka W, Mehlmer N, Maurer-Stroh S, Sammer M, Koranda M, Neumüller R, Betschinger J, Knoblich JA, Teige M, Eisenhaber F.
Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling.
Cell Cycle. 2008 Dec;7(23):3709-19.
PMID: 19029837
- Brouwers N, Sleegers K, Engelborghs S, Maurer-Stroh S, Gijselinck I, van der Zee J, Pickut BA, Van den Broeck M, Mattheijssens M, Peeters K, Schymkowitz J, Rousseau F, Martin JJ, Cruts M, De Deyn PP, Van Broeckhoven C.
Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.
Neurology. 2008 Aug 26;71(9):656-64.
PMID: 18565828
- Eisenhaber B, Eisenhaber F.
Posttranslational modifications and subcellular localization signals: indicators of sequence regions without inherent 3D structure?
Curr Protein Pept Sci. 2007 Apr;8(2):197-203. Review.
PMID: 17430201
- Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.
Towards complete sets of farnesylated and geranylgeranylated proteins.
PLoS Comput Biol. 2007 Apr 6;3(4):e66. Epub 2007 Feb 23.
PMID: 17411337
- Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM.
The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.
Mol Cell. 2005 May 27;18(5):543-53.
PMID: 15916961
- Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R.
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Science. 2004 Nov 19;306(5700):1383-6.
PMID: 15550674
- Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP.
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
Trends Biochem Sci. 2003 Feb;28(2):69-74.
PMID: 12575993
- Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T.
Regulation of chromatin structure by site-specific histone H3 methyltransferases.
Nature. 2000 Aug 10;406(6796):593-9.
PMID: 10949293
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