Protein Sequence Analysis Group
Dr. MAURER-STROH Sebastian
Senior Principal Investigator

Group Members
Dr. MAURER-STROH SebastianPrincipal Investigator
Dr. LIMVIPHUVADH VachiraneeResearch Scientist
Dr. VITHIAGARAN GunalanPostdoctoral Fellow
Dr. KENANOV Dimitar Postdoctoral Fellow
Dr. NISKA JoannaPostdoctoral Fellow
Mr. LEE Tze ChuenResearch Officer
Mr. BEYENE TAYE Biruhalem PhD student
Mr. HAN Xiaochuan Alvin PhD student
Research Overview

Although the complete sequencing of the human and other genomes was almost a decade ago, we find ourselves in the exciting situation that still only a subset of the identified genes is functionally well characterized. Our group embarks on the journey to map the functions of the many remaining uncharacterized genes, and the proteins they are translated to. Furthermore, it is not sufficient to look at the individual components of complex biological systems but rather consider the context of their interaction with each other to better understand how our cells, organs and bodies work.

Based primarily on protein sequence analysis and the analysis of other sequence-associated data, the various aspects of molecular and cellular function (enzymatic activities, posttranslational modifications, cleavage, translocation signals, 3D structures, pathway relationships, etc.) are predicted. Our work is strongly facilitated by the ANNOTATOR group which provides a software service for efficient sequence-analytic workflows. Finally, the hypotheses about protein functions are either followed up by experimental collaborators or they are validated in the Division's own protein biochemical laboratory.
More Details

Selected Publications
  1. Ma J, Eisenhaber F, Maurer-Stroh S.
    Automatic phylogenetic classification of bacterial Beta-lactamase sequences including structural and antibiotic substrate preference information.
    J Bioinform Comput Biol. 2013 Dec;11(6):1343011. doi: 10.1142/S0219720013430117. Epub 2013 Dec 11.
    PubMed PMID: 24372040.

  2. Maurer-Stroh S, Gunalan V, Wong WC, Eisenhaber F.
    A simple shortcut to unsupervised alignment-free phylogenetic genome groupings, even from unassembled sequencing reads.
    J Bioinform Comput Biol. 2013 Dec;11(6):1343005. doi: 10.1142/S0219720013430051. Epub 2013 Dec 2.
    PubMed PMID: 24372034.

  3. Joshi A, Lee RT, Mohl J, Sedano M, Xin KW, Tek NO, Maurer-Stroh S, Garg H.
    Genetic Signatures of HIV-1 Envelope Mediated Bystander Apoptosis.
    J Biol Chem. 2013 Nov 21. [Epub ahead of print]
    PubMed PMID: 24265318.

  4. Lee RT, Gunalan V, Van TD, Le LT, Eisenhaber F, Maurer-Stroh S.
    A new piece in the puzzle of the novel avian-origin influenza a (H7N9) virus.
    Biol Direct. 2013 Oct 26;8(1):26. [Epub ahead of print]
    PubMed PMID: 24160334.

  5. Plasman K, Maurer-Stroh S, Ahmad J, Hao H, Kaiserman D, Sirota FL, Jonckheere V, Bird PI, Gevaert K, Van Damme P.
    Conservation of the extended substrate specificity profiles among homologous granzymes across species.
    Mol Cell Proteomics. 2013 Oct;12(10):2921-34. doi: 10.1074/mcp.M113.028670. Epub 2013 Jun 20.
    PubMed PMID: 23788529; PubMed Central PMCID: PMC3790301.

  6. Guarnaccia T, Carolan LA, Maurer-Stroh S, Lee RT, Job E, Reading PC, Petrie S, McCaw JM, McVernon J, Hurt AC, Kelso A, Mosse J, Barr IG, Laurie KL.
    Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model.
    PLoS Pathog. 2013;9(5):e1003354. doi: 10.1371/journal.ppat.1003354. Epub 2013 May 9.
    PubMed PMID: 23671418; PubMed Central PMCID: PMC3649996.

  7. Tran-Viet KN, Powell C, Barathi VA, Klemm T, Maurer-Stroh S, Limviphuvadh V, Soler V, Ho C, Yanovitch T, Schneider G, Li YJ, Nading E, Metlapally R, Saw SM, Goh L, Rozen S, Young TL.
    Mutations in SCO2 are associated with autosomal-dominant high-grade myopia.
    Am J Hum Genet. 2013 May 2;92(5):820-6. doi: 10.1016/j.ajhg.2013.04.005.
    PubMed PMID: 23643385; PubMed Central PMCID: PMC3644634.

  8. Maurer-Stroh S, Lee RT, Gunalan V, Eisenhaber F.
    The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA.
    Virol J. 2013 May 1;10:139. doi: 10.1186/1743-422X-10-139.
    PubMed PMID: 23635025; PubMed Central PMCID: PMC3673898.

  9. Wong WC, Maurer-Stroh S, Schneider G, Eisenhaber F.
    Transmembrane helix: simple or complex.
    Nucleic Acids Res. 2012 Jul;40(Web Server issue):W370-5. doi: 10.1093/nar/gks379. Epub 2012 May 7.
    PubMed PMID: 22564899; PubMed Central PMCID: PMC3394259.

  10. Hurt AC, Hardie K, Wilson NJ, Deng YM, Osbourn M, Leang SK, Lee RT, Iannello P, Gehrig N, Shaw R, Wark P, Caldwell N, Givney RC, Xue L, Maurer-Stroh S, Dwyer DE, Wang B, Smith DW, Levy A, Booy R, Dixit R, Merritt T, Kelso A, Dalton C, Durrheim D, Barr IG.
    Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia.
    J Infect Dis. 2012 Jul 15;206(2):148-57. doi: 10.1093/infdis/jis337. Epub 2012 May 4.
    PubMed PMID: 22561367; PubMed Central PMCID: PMC3379839.

  11. Tan J, Kuchibhatla D, Sirota FL, Sherman WA, Gattermayer T, Kwoh CY, Eisenhaber F, Schneider G, Maurer-Stroh S.
    Tachyon search speeds up retrieval of similar sequences by several orders of magnitude.
    Bioinformatics. 2012 Jun 15;28(12):1645-6. doi: 10.1093/bioinformatics/bts197. Epub 2012 Apr 23.
    PubMed PMID: 22531216; PubMed Central PMCID: PMC3371831.

  12. Maurer-Stroh S, Debulpaep M, Kuemmerer N, Lopez de la Paz M, Martins IC, Reumers J, Morris KL, Copland A, Serpell L, Serrano L, Schymkowitz JW, Rousseau F.
    Exploring the sequence determinants of amyloid structure using position-specific scoring matrices.
    Nat Methods. 2010 Mar;7(3):237-42. doi: 10.1038/nmeth.1432. Epub 2010 Feb 14.
    PubMed PMID: 20154676.

  13. Maurer-Stroh S, Eisenhaber F.
    Refinement and prediction of protein prenylation motifs.
    Genome Biol. 2005;6(6):R55. Epub 2005 May 27.
    PubMed PMID: 15960807; PubMed Central PMCID: PMC1175975.

  14. Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP.
    The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
    Trends Biochem Sci. 2003 Feb;28(2):69-74.
    PubMed PMID: 12575993.
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