Biography Details
 
Dr. CHIAM Keng Hwee
Senior Principal Investigator


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Biography
 
CHIAM Keng Hwee is a theorist working at the interface of physics and biology, collaborating very closely with experimental groups in developing theories and models for a variety of problems in mechanobiology and biological physics, systems biology, and biological fluid mechanics. He received his Ph.D. in physics from the California Institute of Technology in 2003 and his B.S.E. in physics from the University of Michigan in 1997. Prior to joining the Bioinformatics Institute in 2013, he and his group was located at the Institute of High Performance Computing.
 
Selected Publications
 
  1. Sum Thai Wong, Soo Kng Teo, Sungsu Park, K.-H. Chiam, Evelyn K. F. Yim.
    Anisotropic rigidity sensing on grating topography directs human mesenchymal stem cell elongation.
    Biomechanics and Modeling in Mechanobiology 13, 27 (2014).


  2. Chaitanya Prashant Ursekar, Soo-Kng Teo, Hiroaki Hirata, Ichiro Harada, K.-H. Chiam, Yasuhiro Sawada.
    Design and construction of an equibiaxial cell stretching system that is improved for biochemical analysis.
    PLOS ONE 9, e90665 (2014).


  3. Yen Ling Koon, Cheng Gee Koh, K.-H. Chiam.
    Computational modeling reveals optimal strategy for kinase transport by microtubules to nerve terminals.
    PLOS ONE 9, e92437 (2014).


  4. Shota Yamauchi, Yanyan Hou, Alvin Kunyao Guo, Hiroaki Hirata, Wataru Nakajima, Ai Kia Yip, Cheng-han Yu, Ichiro Harada, K.-H. Chiam, Yasuhiro Sawada, Nobuyuki Tanaka, Keiko Kawauchi.
    p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion.
    Journal of Cell Biology 204, 1191 (2014).


  5. Jie Shi Chua, Choon-Peng Chng+, Aung Aung Kywe Moe, Jason Y. Tann, Eyleen L. Goh, K.-H. Chiam, Evelyn K. Yim.
    Extending neurites sense the depth of the underlying topography during neuronal differentiation and contact guidance.
    Biomaterials 35, 7750 (2014).


  6. Hiroaki Hirata, K.-H. Chiam, Chwee Teck Lim, Masahiro Sokabe.
    Actin flow and talin dynamics govern rigidity sensing in the actin-integrin linkage through talin extension.
    Journal of the Royal Society Interface 11, 20140734 (2014).


  7. Sum Thai Wong, Soo Kng Teo, Sungsu Park, K.-H. Chiam, Evelyn K. F. Yim.
    Anisotropic rigidity sensing on grating topography directs human mesenchymal stem cell elongation.
    Biomechanics and Modeling in Mechanobiology 13, 27 (2014).


  8. Seong-Won Nam, Chen Qian, So Hyun Kim, Danny van Noort, K.-H. Chiam, Sungsu Park.
    C. elegans sensing of and entrainment along obstacles require different neurons at different body locations.
    Scientific Reports 3, 3247 (2013).


  9. Chen Qian, Chui Ching Wong, Sanjay Swarup, K.-H. Chiam.
    Bacterial tethering analysis reveals "run-reverse-turn" mechanism for Pseudomonas species motility.
    Applied and Environmental Microbiology 79, 4734 (2013) (spotlight article).


  10. Fong Yin Lim, Yen Ling Koon, K.-H. Chiam.
    A computational model of amoeboid cell migration.
    Computer Methods in Biomechanics and Biomedical Engineering, 16, 1085 (2013).


  11. Ai Kia Yip, Katsuhiko Iwasaki, Chaitanya Ursekar, Hiroaki Machiyama, Mayur Saxena, Huiling Chen, Ichiro Harada, K.-H. Chiam, Yasuhiro Sawada.
    Cellular response to substrate rigidity is governed by either stress or strain.
    Biophysical Journal 104, 19 (2013).


  12. Fong Yin Lim, K.-H. Chiam, L. Mahadevan.
    The size, shape, and dynamics of cellular blebs.
    Europhysics Letters 100, 28004 (2012).


  13. Keng Boon Wee, Wee Kheng Yio, Uttam Surana, K.-H. Chiam.
    Transcription factor oscillations induce differential gene expressions.
    Biophysical Journal 102, 2413 (2012).


  14. Marcus Tan, Duc Vinh Le, K.-H. Chiam.
    Hydrodynamic diffusion of a suspension of elastic capsules in bounded simple shear flow.
    Soft Matter 8, 2243 (2012).


  15. Yukai Zeng, Ai Kia Yip, Soo Kng Teo, K.-H. Chiam.
    A three-dimensional random network model of the cytoskeleton and its role in mechanotransduction and nucleus deformation.
    Biomechanics and Modeling in Mechanobiology 11, 49 (2012).


  16. Tanny Lai, K.-H. Chiam.
    Mechanochemical modeling of cell migration on substrates of varying stiffness.
    Physical Review E 84, 061907 (2011).


  17. Duc Vinh Le, K.-H. Chiam.
    Hydrodynamic interaction between two non-spherical capsules in shear flow.
    Physical Review E 84, 056322 (2011).


  18. Meredith Calvert, Graham Wright, Fong Yew Leong, K.-H. Chiam, Yinxiao Chen, Greg Jedd, Mohan Balasubramanian.
    Myosin concentration underlies cell-size dependent scalability of actomyosin ring constriction.
    Journal of Cell Biology 195, 799 (2011) (selected by Faculty of 1000).


  19. Yukai Zeng, Tanny Lai, Cheng Gee Koh, Phil LeDuc, K.-H. Chiam.
    Investigating circular dorsal ruffles through varying substrate stiffness and mathematical modeling.
    Biophysical Journal 101, 2122 (2011) (featured article).


  20. Fong Yew Leong, Qingsen Li, Chwee Teck Lim, K.-H. Chiam.
    Modeling cell entry into a micro-channel.
    Biomechanics and Modeling in Mechanobiology 10, 755 (2011).


  21. Ramanujam Srinivasan, Mithilesh Mishra, Fong Yew Leong, K.-H. Chiam, Mohan Balasubramanian.
    Bacillus anthracis tubulin-related protein Ba-TubZ assembles force-generating polymers.
    Cytoskeleton 68, 501 (2011).


  22. Candice Yam, Yue He, Dan Zhang, K.-H. Chiam, Snezhana Oliferenko.
    Divergent strategies for controlling the nuclear membrane satisfy geometric constraints during nuclear division.
    Current Biology 21, 1314 (2011).


  23. Raymond Quek, Duc Vinh Le, K.-H. Chiam.
    Separation of deformable particles in deterministic lateral displacement devices.
    Physical Review E 83, 056301 (2011).


 

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