Biography Details
Head of Division
Areas of Research Interest
Frank Eisenhaber's research interest is focused on the discovery of new biomolecular mechanisms from omics and clinical data with theoretical and biochemical approaches and the functional characterization of yet uncharacterized genes and pathways. Frank Eisenhaber is one of the scientists credited with the discovery of the SET domain methyltransferases, ATGL, kleisins, many new protein domain functions and with the development of accurate prediction tools for posttranslational modifications and subcellular localizations.
Frank Eisenhaber studied mathematics at the Humboldt-University in Berlin and biophysics and medicine at the Pirogov Medical University in Moscow. He was awarded a MD in 1985. Three years later, he received the PhD in molecular biology from the Engelhardt Institute of Molecular Biology in Moscow (supervision by Dr. Vladimir Gayevich Tumanyan). After postdoctoral work at the Institute of Molecular Biology in Berlin-Buch (1989-1991) and at the EMBL in Heidelberg (1991-1999), he worked as teamleader of the bioinformatics research group and head of the general IT department at the Institute of Molecular Pathology (IMP) in Vienna (1999-2007). Since August 2007, he is the Director of the Bioinformatics Institute A*STAR Singapore.
Selected Publications
  1. Mah T, Yap X, Limviphuvadh V, Li N, Sridharan S, Kuralmani V, Feng M, Liem N, Adhikari S, Yong W, Soo RA, Maurer-Stroh S, Eisenhaber F, Tong J.
    Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.
    BMC Genomics. 2014 Dec 8;15 Suppl 9:S20. doi: 10.1186/1471-2164-15-S9-S20. Epub 2014 Dec 8.

  2. Dip PV, Kamariah N, Subramanian Manimekalai MS, Nartey W, Balakrishna AM, Eisenhaber F, Eisenhaber B, Grüber G.
    Structure, mechanism and ensemble formation of the alkylhydroperoxide reductase subunits AhpC and AhpF from Escherichia coli.
    Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):2848-62. doi: 10.1107/S1399004714019233. Epub 2014 Oct 16.

  3. Dip PV, Kamariah N, Nartey W, Beushausen C, Kostyuchenko VA, Ng TS, Lok SM, Saw WG, Eisenhaber F, Eisenhaber B, Grüber G.
    Key roles of the Escherichia coli AhpC C-terminus in assembly and catalysis of alkylhydroperoxide reductase, an enzyme essential for the alleviation of oxidative stress.
    Biochim Biophys Acta. 2014 Dec;1837(12):1932-43.

  4. Maurer-Stroh S, Li Y, Bastien N, Gunalan V, Lee RT, Eisenhaber F, Booth TF.
    Potential human adaptation mutation of influenza A(H5N1) virus, Canada.
    Emerg Infect Dis. 2014 Sep;20(9):1580-2. doi: 10.3201/eid2009.140240. No abstract available.

  5. Eisenhaber F.
    Unix interfaces, Kleisli, bucandin structure, etc. -- the heroic beginning of bioinformatics in Singapore.
    J Bioinform Comput Biol. 2014 Jun;12(3):1471002. doi: 10.1142/S0219720014710024. Epub 2014 Jun 5.

  6. Eisenhaber F, Sherman WA.
    10 years for the Journal of Bioinformatics and Computational Biology (2003-2013) -- a retrospective.
    J Bioinform Comput Biol. 2014 Jun;12(3):1471001. doi: 10.1142/S0219720014710012. Epub 2014 May 21.

  7. Wong WC, Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation.
    BMC Bioinformatics. 2014 Jun 2;15:166. doi: 10.1186/1471-2105-15-166.

  8. Eisenhaber B, Eisenhaber S, Kwang TY, Grüber G, Eisenhaber F.
    Transamidase subunit GAA1/GPAA1 is a M28 family metallo-peptide-synthetase that catalyzes the peptide bond formation between the substrate protein's omega-site and the GPI lipid anchor's phosphoethanolamine.
    Cell Cycle. 2014;13(12):1912-7. doi: 10.4161/cc.28761. Epub 2014 Apr 17.

  9. Eisenhaber F, Sung WK, Wong L.
    International Conference on Genome Informatics (GIW 2013) in Singapore: Introduction to the systems biology contributions.
    BMC Syst Biol. 2013;7 Suppl 6:I1. doi: 10.1186/1752-0509-7-S6-I1. Epub 2013 Dec 13. No abstract available.

  10. Ma J, Eisenhaber F, Maurer-Stroh S.
    Automatic phylogenetic classification of bacterial beta-lactamase sequences including structural and antibiotic substrate preference information.
    J Bioinform Comput Biol. 2013 Dec;11(6):1343011. doi: 10.1142/S0219720013430117. Epub 2013 Dec 11.

  11. Maurer-Stroh S, Gunalan V, Wong WC, Eisenhaber F.
    A simple shortcut to unsupervised alignment-free phylogenetic genome groupings, even from unassembled sequencing reads.
    J Bioinform Comput Biol. 2013 Dec;11(6):1343005. doi: 10.1142/S0219720013430051. Epub 2013 Dec 2.

  12. Lee RT, Gunalan V, Van TD, Le LT, Eisenhaber F, Maurer-Stroh S.
    A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus.
    Biol Direct. 2013 Oct 26;8:26. doi: 10.1186/1745-6150-8-26.

  13. Goncearenco A, Mitternacht S, Yong T, Eisenhaber B, Eisenhaber F, Berezovsky IN.
    SPACER: Server for predicting allosteric communication and effects of regulation.
    Nucleic Acids Res. 2013 Jul;41(Web Server issue):W266-72. doi: 10.1093/nar/gkt460. Epub 2013 Jun 3.

  14. Maurer-Stroh S, Lee RT, Gunalan V, Eisenhaber F.
    The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA.
    Virol J. 2013 May 1;10:139. doi: 10.1186/1743-422X-10-139.

  15. Saw WG, Eisenhaber B, Eisenhaber F, Grüber G.
    Low-resolution structure of the soluble domain GPAA1 (yGPAA170-247) of the glycosylphosphatidylinositol transamidase subunit GPAA1 from Saccharomyces cerevisiae.
    Biosci Rep. 2013 Mar 28;33(2):e00033. doi: 10.1042/BSR20120107.

  16. Maurer-Stroh S, Gao H, Han H, Baeten L, Schymkowitz J, Rousseau F, Zhang L, Eisenhaber F.
    Motif discovery with data mining in 3D protein structure databases: discovery, validation and prediction of the U-shape zinc binding ("Huf-Zinc") motif.
    J Bioinform Comput Biol. 2013 Feb;11(1):1340008. doi: 10.1142/S0219720013400088. Epub 2013 Jan 16.

  17. Sirota FL, Batagov A, Schneider G, Eisenhaber B, Eisenhaber F, Maurer-Stroh S.
    Beware of moving targets: reference proteome content fluctuates substantially over the years.
    J Bioinform Comput Biol. 2012 Dec;10(6):1250020. doi: 10.1142/S0219720012500205. Epub 2012 Aug 7.

  18. Eisenhaber F.
    A decade after the first full human genome sequencing: when will we understand our own genome?
    J Bioinform Comput Biol. 2012 Oct;10(5):1271001. doi: 10.1142/S0219720012710011. Epub 2012 Jun 22.

  19. Wong WC, Maurer-Stroh S, Schneider G, Eisenhaber F.
    Transmembrane helix: simple or complex.
    Nucleic Acids Res. 2012 Jul;40(Web Server issue):W370-5. doi: 10.1093/nar/gks379. Epub 2012 May 7.

  20. Tan J, Kuchibhatla D, Sirota FL, Sherman WA, Gattermayer T, Kwoh CY, Eisenhaber F, Schneider G, Maurer-Stroh S.
    Tachyon search speeds up retrieval of similar sequences by several orders of magnitude.
    Bioinformatics. 2012 Jun 15;28(12):1645-6. doi: 10.1093/bioinformatics/bts197. Epub 2012 Apr 23.

  21. Eisenhaber B, Sammer M, Lua WH, Benetka W, Liew LL, Yu W, Lee HK, Koranda M, Eisenhaber F, Adhikari S.
    Nuclear import of a lipid-modified transcription factor: mobilization of NFAT5 isoform a by osmotic stress.
    Cell Cycle. 2011 Nov 15;10(22):3897-911. doi: 10.4161/cc.10.22.18043. Epub 2011 Nov 15.

  22. Kunze M, Neuberger G, Maurer-Stroh S, Ma J, Eck T, Braverman N, Schmid JA, Eisenhaber F, Berger J.
    Structural requirements for interaction of peroxisomal targeting signal 2 and its receptor PEX7.
    J Biol Chem. 2011 Dec 30;286(52):45048-62. doi: 10.1074/jbc.M111.301853. Epub 2011 Nov 5.

  23. Wong WC, Maurer-Stroh S, Eisenhaber F.
    Not all transmembrane helices are born equal: Towards the extension of the sequence homology concept to membrane proteins.
    Biol Direct. 2011 Oct 25;6:57. doi: 10.1186/1745-6150-6-57.

  24. Kamariah N, Eisenhaber F, Adhikari S, Eisenhaber B, Grüber G.
    Purification and crystallization of yeast glycosylphosphatidylinositol transamidase subunit PIG-S (PIG-S(71-467)).
    Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):896-9. doi: 10.1107/S1744309111024080. Epub 2011 Jul 19.

  25. Dellago H, Löscher M, Ajuh P, Ryder U, Kaisermayer C, Grillari-Voglauer R, Fortschegger K, Gross S, Gstraunthaler A, Borth N, Eisenhaber F, Lamond AI, Grillari J.
    Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing.
    Biochem J. 2011 Aug 15;438(1):81-91. doi: 10.1042/BJ20110183.

  26. Wong WC, Maurer-Stroh S, Eisenhaber F.
    The Janus-faced E-values of HMMER2: extreme value distribution or logistic function?
    J Bioinform Comput Biol. 2011 Feb;9(1):179-206.

  27. Prokesch A, Bogner-Strauss JG, Hackl H, Rieder D, Neuhold C, Walenta E, Krogsdam A, Scheideler M, Papak C, Wong WC, Vinson C, Eisenhaber F, Trajanoski Z.
    Arxes: retrotransposed genes required for adipogenesis.
    Nucleic Acids Res. 2011 Apr;39(8):3224-39. doi: 10.1093/nar/gkq1289. Epub 2010 Dec 21.

  28. Toh YK, Kamariah N, Maurer-Stroh S, Roessle M, Eisenhaber F, Adhikari S, Eisenhaber B, Grüber G.
    Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast.
    J Struct Biol. 2011 Feb;173(2):271-81. doi: 10.1016/j.jsb.2010.11.026. Epub 2010 Dec 4.

  29. Lee VJ, Yap J, Maurer-Stroh S, Lee RT, Eisenhaber F, Tay JK, Ting PJ, Loh JP, Wong CW, Tan BH, Koay ES, Kelly PM, Hibberd ML.
    Investigation of causes of oseltamivir chemoprophylaxis failures during influenza A (H1N1-2009) outbreaks.
    J Clin Virol. 2011 Feb;50(2):104-8. doi: 10.1016/j.jcv.2010.10.004. Epub 2010 Nov 19.

  30. Lee RT, Santos CL, de Paiva TM, Cui L, Sirota FL, Eisenhaber F, Maurer-Stroh S.
    All that glitters is not gold--founder effects complicate associations of flu mutations to disease severity.
    Virol J. 2010 Nov 1;7:297. doi: 10.1186/1743-422X-7-297.

  31. Maurer-Stroh S, Paing SS, Lee RT, Eisenhaber F.
    Sporadic human cases of swine-origin influenza before 2009 share the Sa epitope.
    Cell Cycle. 2010 Sep 15;9(18):3826-8. doi: 10.4161/cc.9.18.13166. Epub 2010 Sep 26. No abstract available.

  32. Dhir S, Pacurar M, Franklin D, Gáspári Z, Kertész-Farkas A, Kocsor A, Eisenhaber F, Pongor S.
    Detecting atypical examples of known domain types by sequence similarity searching: the SBASE domain library approach.
    Curr Protein Pept Sci. 2010 Nov;11(7):538-49. Review.

  33. Limviphuvadh V, Chua LL, Rahim RA, Eisenhaber F, Maurer-Stroh S, Adhikari S.
    Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2.
    BMC Biochem. 2010 Sep 24;11:39. doi: 10.1186/1471-2091-11-39.

  34. Wong WC, Maurer-Stroh S, Eisenhaber F.
    More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology.
    PLoS Comput Biol. 2010 Jul 29;6(7):e1000867. doi: 10.1371/journal.pcbi.1000867.

  35. Bogner-Strauss JG, Prokesch A, Sanchez-Cabo F, Rieder D, Hackl H, Duszka K, Krogsdam A, Di Camillo B, Walenta E, Klatzer A, Lass A, Pinent M, Wong WC, Eisenhaber F, Trajanoski Z.
    Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPAR?.
    Cell Mol Life Sci. 2010 Dec;67(23):4049-64. doi: 10.1007/s00018-010-0424-5. Epub 2010 Jun 15.

  36. Van Damme P, Maurer-Stroh S, Hao H, Colaert N, Timmerman E, Eisenhaber F, Vandekerckhove J, Gevaert K.
    The substrate specificity profile of human granzyme A.
    Biol Chem. 2010 Aug;391(8):983-97. doi: 10.1515/BC.2010.096.

  37. Maurer-Stroh S, Lee RT, Eisenhaber F, Cui L, Phuah SP, Lin RT.
    A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus.
    PLoS Curr. 2010 Jun 1;2:RRN1162.

  38. Eisenhaber B, Eisenhaber F.
    Prediction of posttranslational modification of proteins from their amino acid sequence.
    Methods Mol Biol. 2010;609:365-84. doi: 10.1007/978-1-60327-241-4_21. Review.

  39. Schneider G, Wildpaner M, Sirota FL, Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    Integrated tools for biomolecular sequence-based function prediction as exemplified by the ANNOTATOR software environment.
    Methods Mol Biol. 2010;609:257-67. doi: 10.1007/978-1-60327-241-4_15.

  40. Ooi HS, Schneider G, Chan YL, Lim TT, Eisenhaber B, Eisenhaber F.
    Databases of protein-protein interactions and complexes.
    Methods Mol Biol. 2010;609:145-59. doi: 10.1007/978-1-60327-241-4_9. Review.

  41. Ooi HS, Schneider G, Lim TT, Chan YL, Eisenhaber B, Eisenhaber F.
    Biomolecular pathway databases.
    Methods Mol Biol. 2010;609:129-44. doi: 10.1007/978-1-60327-241-4_8. Review.

  42. Sirota FL, Ooi HS, Gattermayer T, Schneider G, Eisenhaber F, Maurer-Stroh S.
    Parameterization of disorder predictors for large-scale applications requiring high specificity by using an extended benchmark dataset.
    BMC Genomics. 2010 Feb 10;11 Suppl 1:S15. doi: 10.1186/1471-2164-11-S1-S15.

  43. Mujezinovic N, Schneider G, Wildpaner M, Mechtler K, Eisenhaber F.
    Reducing the haystack to find the needle: improved protein identification after fast elimination of non-interpretable peptide MS/MS spectra and noise reduction.
    BMC Genomics. 2010 Feb 10;11 Suppl 1:S13. doi: 10.1186/1471-2164-11-S1-S13.

  44. Limviphuvadh V, Chua LL, Eisenhaber F, Adhikari S, Maurer-Stroh S.
    Is LGI2 the candidate gene for partial epilepsy with pericentral spikes?
    J Bioinform Comput Biol. 2010 Feb;8(1):117-27.

  45. Kawase-Koga Y, Low R, Otaegi G, Pollock A, Deng H, Eisenhaber F, Maurer-Stroh S, Sun T.
    RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells.
    J Cell Sci. 2010 Feb 15;123(Pt 4):586-94. doi: 10.1242/jcs.059659. Epub 2010 Jan 26.

  46. Ranganathan S, Eisenhaber F, Tong JC, Tan TW.
    Extending Asia Pacific bioinformatics into new realms in the "-omics" era.
    BMC Genomics. 2009 Dec 3;10 Suppl 3:S1. doi: 10.1186/1471-2164-10-S3-S1.

  47. Tse WK, Eisenhaber B, Ho SH, Ng Q, Eisenhaber F, Jiang YJ.
    Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development.
    BMC Genomics. 2009 Dec 30;10:637. doi: 10.1186/1471-2164-10-637.

  48. Eisenhaber F, Kwoh CK, Ng SK, Sung WK, Wong L.
    Brief overview of bioinformatics activities in Singapore.
    PLoS Comput Biol. 2009 Sep;5(9):e1000508. doi: 10.1371/journal.pcbi.1000508. Epub 2009 Sep 25. No abstract available. Erratum in: PLoS Comput Biol. 2009 Nov;5(11). doi: 10.1371/annotation/5d07cf0b-75f8-4452-a932-46574f5faf3f. Sung, Wing-King [corrected to Sung, Wing-Kin].

  49. Grillari J, Löscher M, Denegri M, Lee K, Fortschegger K, Eisenhaber F, Ajuh P, Lamond AI, Katinger H, Grillari-Voglauer R.
    Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.
    J Biol Chem. 2009 Oct 16;284(42):29193-204. doi: 10.1074/jbc.M109.036632. Epub 2009 Jul 29.

  50. Maurer-Stroh S, Ma J, Lee RT, Sirota FL, Eisenhaber F.
    Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites.
    Biol Direct. 2009 May 20;4:18; discussion 18. doi: 10.1186/1745-6150-4-18.

  51. Ooi HS, Kwo CY, Wildpaner M, Sirota FL, Eisenhaber B, Maurer-Stroh S, Wong WC, Schleiffer A, Eisenhaber F, Schneider G.
    ANNIE: integrated de novo protein sequence annotation.
    Nucleic Acids Res. 2009 Jul;37(Web Server issue):W435-40. doi: 10.1093/nar/gkp254. Epub 2009 Apr 23.

  52. Dhar PK, Thwin CS, Tun K, Tsumoto Y, Maurer-Stroh S, Eisenhaber F, Surana U.
    Synthesizing non-natural parts from natural genomic template.
    J Biol Eng. 2009 Feb 3;3:2. doi: 10.1186/1754-1611-3-2.

  53. Benetka W, Mehlmer N, Maurer-Stroh S, Sammer M, Koranda M, Neumüller R, Betschinger J, Knoblich JA, Teige M, Eisenhaber F.
    Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling.
    Cell Cycle. 2008 Dec;7(23):3709-19. Epub 2008 Dec 13. Erratum in: Cell Cycle. 2009 Feb 1;8(3):508-9.

  54. Wong WC, Loh M, Eisenhaber F.
    On the necessity of different statistical treatment for Illumina BeadChip and Affymetrix GeneChip data and its significance for biological interpretation.
    Biol Direct. 2008 Jun 3;3:23. doi: 10.1186/1745-6150-3-23.

  55. Eisenhaber B, Eisenhaber F.
    Posttranslational modifications and subcellular localization signals: indicators of sequence regions without inherent 3D structure?
    Curr Protein Pept Sci. 2007 Apr;8(2):197-203. Review.

  56. Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.
    Towards complete sets of farnesylated and geranylgeranylated proteins.
    PLoS Comput Biol. 2007 Apr 6;3(4):e66. Epub 2007 Feb 23.

  57. Eisenhaber B, Chumak N, Eisenhaber F, Hauser MT.
    The ring between ring fingers (RBR) protein family.
    Genome Biol. 2007;8(3):209. Review.

  58. Neuberger G, Schneider G, Eisenhaber F.
    pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model.
    Biol Direct. 2007 Jan 12;2:1.

  59. Mujezinovic N, Raidl G, Hutchins JR, Peters JM, Mechtler K, Eisenhaber F.
    Cleaning of raw peptide MS/MS spectra: improved protein identification following deconvolution of multiply charged peaks, isotope clusters, and removal of background noise.
    Proteomics. 2006 Oct;6(19):5117-31.

  60. Novatchkova M, Schneider G, Fritz R, Eisenhaber F, Schleiffer A.
    DOUTfinder--identification of distant domain outliers using subsignificant sequence similarity.
    Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W214-8.

  61. Watrin E, Schleiffer A, Tanaka K, Eisenhaber F, Nasmyth K, Peters JM.
    Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression.
    Curr Biol. 2006 May 9;16(9):863-74.

  62. Schneider G, Neuberger G, Wildpaner M, Tian S, Berezovsky I, Eisenhaber F.
    Application of a sensitive collection heuristic for very large protein families: evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases.
    BMC Bioinformatics. 2006 Mar 21;7:164.

  63. Benetka W, Koranda M, Maurer-Stroh S, Pittner F, Eisenhaber F.
    Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo.
    BMC Biochem. 2006 Feb 28;7:6.

  64. Hackl H, Burkard TR, Sturn A, Rubio R, Schleiffer A, Tian S, Quackenbush J, Eisenhaber F, Trajanoski Z.
    Molecular processes during fat cell development revealed by gene expression profiling and functional annotation.
    Genome Biol. 2005;6(13):R108. Epub 2005 Dec 19.

  65. Grillari J, Ajuh P, Stadler G, Löscher M, Voglauer R, Ernst W, Chusainow J, Eisenhaber F, Pokar M, Fortschegger K, Grey M, Lamond AI, Katinger H.
    SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly.
    Nucleic Acids Res. 2005 Dec 6;33(21):6868-83. Print 2005.

  66. Novatchkova M, Wildpaner M, Schweizer D, Eisenhaber F.
    PhyloDome--visualization of taxonomic distributions of domains occurring in eukaryote protein sequence sets.
    Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W121-5.

  67. Maurer-Stroh S, Eisenhaber F.
    Refinement and prediction of protein prenylation motifs.
    Genome Biol. 2005;6(6):R55. Epub 2005 May 27.

  68. Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM.
    The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.
    Mol Cell. 2005 May 27;18(5):543-53.

  69. Novatchkova M, Bachmair A, Eisenhaber B, Eisenhaber F.
    Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family.
    BMC Bioinformatics. 2005 Feb 7;6:22.

  70. Betschinger J, Eisenhaber F, Knoblich JA.
    Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae.
    Curr Biol. 2005 Feb 8;15(3):276-82.

  71. Neuberger G, Kunze M, Eisenhaber F, Berger J, Hartig A, Brocard C.
    Hidden localization motifs: naturally occurring peroxisomal targeting signals in non-peroxisomal proteins.
    Genome Biol. 2004;5(12):R97. Epub 2004 Nov 30.

  72. Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R.
    Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
    Science. 2004 Nov 19;306(5700):1383-6.

  73. Novatchkova M, Budhiraja R, Coupland G, Eisenhaber F, Bachmair A.
    SUMO conjugation in plants.
    Planta. 2004 Nov;220(1):1-8. Epub 2004 Sep 23. Review.

  74. Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T.
    Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.
    Genes Dev. 2004 Sep 1;18(17):2108-19.

  75. Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T.
    Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes.
    Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10984-9. Epub 2004 Jul 19.

  76. Lorenz A, Wells JL, Pryce DW, Novatchkova M, Eisenhaber F, McFarlane RJ, Loidl J.
    S. pombe meiotic linear elements contain proteins related to synaptonemal complex components.
    J Cell Sci. 2004 Jul 1;117(Pt 15):3343-51.

  77. Eisenhaber B, Eisenhaber F, Maurer-Stroh S, Neuberger G.
    Prediction of sequence signals for lipid post-translational modifications: insights from case studies.
    Proteomics. 2004 Jun;4(6):1614-25.

  78. Maurer-Stroh S, Eisenhaber F.
    Myristoylation of viral and bacterial proteins.
    Trends Microbiol. 2004 Apr;12(4):178-85. Review. No abstract available.

  79. Eisenhaber B, Schneider G, Wildpaner M, Eisenhaber F.
    A sensitive predictor for potential GPI lipid modification sites in fungal protein sequences and its application to genome-wide studies for Aspergillus nidulans, Candida albicans, Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombe.
    J Mol Biol. 2004 Mar 19;337(2):243-53.

  80. Maurer-Stroh S, Gouda M, Novatchkova M, Schleiffer A, Schneider G, Sirota FL, Wildpaner M, Hayashi N, Eisenhaber F.
    MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins.
    Genome Biol. 2004;5(3):R21. Epub 2004 Feb 13.

  81. Rabitsch KP, Gregan J, Schleiffer A, Javerzat JP, Eisenhaber F, Nasmyth K.
    Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II.
    Curr Biol. 2004 Feb 17;14(4):287-301.

  82. Novatchkova M, Eisenhaber F.
    Linking transcriptional mediators via the GACKIX domain super family.
    Curr Biol. 2004 Jan 20;14(2):R54-5. No abstract available.

  83. Cserzo M, Eisenhaber F, Eisenhaber B, Simon I.
    TM or not TM: transmembrane protein prediction with low false positive rate using DAS-TMfilter.
    Bioinformatics. 2004 Jan 1;20(1):136-7.

  84. Eisenhaber B, Wildpaner M, Schultz CJ, Borner GH, Dupree P, Eisenhaber F.
    Glycosylphosphatidylinositol lipid anchoring of plant proteins. Sensitive prediction from sequence- and genome-wide studies for Arabidopsis and rice.
    Plant Physiol. 2003 Dec;133(4):1691-701.

  85. Washietl S, Eisenhaber F.
    Reannotation of the CELO genome characterizes a set of previously unassigned open reading frames and points to novel modes of host interaction in avian adenoviruses.
    BMC Bioinformatics. 2003 Nov 7;4:55.

  86. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM.
    TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.
    Curr Biol. 2003 Sep 2;13(17):1459-68.

  87. Maurer-Stroh S, Washietl S, Eisenhaber F.
    Protein prenyltransferases: anchor size, pseudogenes and parasites.
    Biol Chem. 2003 Jul;384(7):977-89. Review.

  88. Eisenhaber F, Eisenhaber B, Kubina W, Maurer-Stroh S, Neuberger G, Schneider G, Wildpaner M.
    Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1.
    Nucleic Acids Res. 2003 Jul 1;31(13):3631-4.

  89. Novatchkova M, Leibbrandt A, Werzowa J, Neubüser A, Eisenhaber F.
    The STIR-domain superfamily in signal transduction, development and immunity.
    Trends Biochem Sci. 2003 May;28(5):226-9. Review.

  90. Wick N, Luedemann S, Vietor I, Cotten M, Wildpaner M, Schneider G, Eisenhaber F, Huber LA.
    Induction of short interspersed nuclear repeat-containing transcripts in epithelial cells upon infection with a chicken adenovirus.
    J Mol Biol. 2003 May 9;328(4):779-90.

  91. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence.
    J Mol Biol. 2003 May 2;328(3):581-92.

  92. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences.
    J Mol Biol. 2003 May 2;328(3):567-79.

  93. Maurer-Stroh S, Washietl S, Eisenhaber F.
    Protein prenyltransferases.
    Genome Biol. 2003;4(4):212. Epub 2003 Apr 1. Review.

  94. Schleiffer A, Kaitna S, Maurer-Stroh S, Glotzer M, Nasmyth K, Eisenhaber F.
    Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
    Mol Cell. 2003 Mar;11(3):571-5.

  95. Eisenhaber B, Maurer-Stroh S, Novatchkova M, Schneider G, Eisenhaber F.
    Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins.
    Bioessays. 2003 Apr;25(4):367-85. Review.

  96. Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP.
    The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
    Trends Biochem Sci. 2003 Feb;28(2):69-74.

  97. Cserzö M, Eisenhaber F, Eisenhaber B, Simon I.
    On filtering false positive transmembrane protein predictions.
    Protein Eng. 2002 Sep;15(9):745-52.

  98. Novatchkova M, Eisenhaber F.
    A CH domain-containing N terminus in NuMA?
    Protein Sci. 2002 Oct;11(10):2281-4.

  99. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence.
    J Mol Biol. 2002 Apr 5;317(4):541-57.

  100. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences.
    J Mol Biol. 2002 Apr 5;317(4):523-40.

  101. Ivanov D, Schleiffer A, Eisenhaber F, Mechtler K, Haering CH, Nasmyth K.
    Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion.
    Curr Biol. 2002 Feb 19;12(4):323-8.

  102. Wildpaner M, Schneider G, Schleiffer A, Eisenhaber F.
    Taxonomy workbench.
    Bioinformatics. 2001 Dec;17(12):1179-82.

  103. Novatchkova M, Eisenhaber F.
    Can molecular mechanisms of biological processes be extracted from expression profiles? Case study: endothelial contribution to tumor-induced angiogenesis.
    Bioessays. 2001 Dec;23(12):1159-75. Review.

  104. Bachmair A, Novatchkova M, Potuschak T, Eisenhaber F.
    Ubiquitylation in plants: a post-genomic look at a post-translational modification.
    Trends Plant Sci. 2001 Oct;6(10):463-70. Review.

  105. Christian S, Ahorn H, Novatchkova M, Garin-Chesa P, Park JE, Weber G, Eisenhaber F, Rettig WJ, Lenter MC.
    Molecular cloning and characterization of EndoGlyx-1, an EMILIN-like multisubunit glycoprotein of vascular endothelium.
    J Biol Chem. 2001 Dec 21;276(51):48588-95. Epub 2001 Sep 14.

  106. Eisenhaber F, Wechselberger C, Kreil G.
    The Brix domain protein family -- a key to the ribosomal biogenesis pathway?
    Trends Biochem Sci. 2001 Jun;26(6):345-7.

  107. Eisenhaber B, Bork P, Eisenhaber F.
    Post-translational GPI lipid anchor modification of proteins in kingdoms of life: analysis of protein sequence data from complete genomes.
    Protein Eng. 2001 Jan;14(1):17-25.

  108. Panizza S, Tanaka T, Hochwagen A, Eisenhaber F, Nasmyth K.
    Pds5 cooperates with cohesin in maintaining sister chromatid cohesion.
    Curr Biol. 2000 Dec 14-28;10(24):1557-64.

  109. Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC.
    Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium.
    J Biol Chem. 2001 Mar 9;276(10):7408-14. Epub 2000 Nov 17.

  110. Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T.
    Regulation of chromatin structure by site-specific histone H3 methyltransferases.
    Nature. 2000 Aug 10;406(6796):593-9.

  111. Eisenhaber B, Bork P, Yuan Y, Löffler G, Eisenhaber F.
    Automated annotation of GPI anchor sites: case study C. elegans.
    Trends Biochem Sci. 2000 Jul;25(7):340-1. No abstract available.

  112. Senti K, Keleman K, Eisenhaber F, Dickson BJ.
    brakeless is required for lamina targeting of R1-R6 axons in the Drosophila visual system.
    Development. 2000 Jun;127(11):2291-301.

  113. Eisenhaber B, Bork P, Eisenhaber F.
    Prediction of potential GPI-modification sites in proprotein sequences.
    J Mol Biol. 1999 Sep 24;292(3):741-58.

  114. Eisenhaber F, Bork P.
    Evaluation of human-readable annotation in biomolecular sequence databases with biological rule libraries.
    Bioinformatics. 1999 Jul-Aug;15(7-8):528-35.

  115. Sunyaev SR, Eisenhaber F, Rodchenkov IV, Eisenhaber B, Tumanyan VG, Kuznetsov EN.
    PSIC: profile extraction from sequence alignments with position-specific counts of independent observations.
    Protein Eng. 1999 May;12(5):387-94.

  116. Eisenhaber B, Bork P, Eisenhaber F.
    Sequence properties of GPI-anchored proteins near the omega-site: constraints for the polypeptide binding site of the putative transamidase.
    Protein Eng. 1998 Dec;11(12):1155-61.

  117. Bork P, Dandekar T, Diaz-Lazcoz Y, Eisenhaber F, Huynen M, Yuan Y.
    Predicting function: from genes to genomes and back.
    J Mol Biol. 1998 Nov 6;283(4):707-25. Review.

  118. Eisenhaber F, Bork P.
    Wanted: subcellular localization of proteins based on sequence.
    Trends Cell Biol. 1998 Apr;8(4):169-70. Review. No abstract available.

  119. Huynen M, Doerks T, Eisenhaber F, Orengo C, Sunyaev S, Yuan Y, Bork P.
    Homology-based fold predictions for Mycoplasma genitalium proteins.
    J Mol Biol. 1998 Jul 17;280(3):323-6.

  120. Sunyaev SR, Eisenhaber F, Argos P, Kuznetsov EN, Tumanyan VG.
    Are knowledge-based potentials derived from protein structure sets discriminative with respect to amino acid types?
    Proteins. 1998 May 15;31(3):225-46. Review.

  121. Bork P, Dandekar T, Eisenhaber F, Huynen M.
    Characterization of targeting domains by sequence analysis: glycogen-binding domains in protein phosphatases.
    J Mol Med (Berl). 1998 Feb;76(2):77-9. No abstract available.

  122. Eisenhaber F, Argos P.
    Hydrophobic regions on protein surfaces: definition based on hydration shell structure and a quick method for their computation.
    Protein Eng. 1996 Dec;9(12):1121-33.

  123. Eisenhaber F.
    Hydrophobic regions on protein surfaces. Derivation of the solvation energy from their area distribution in crystallographic protein structures.
    Protein Sci. 1996 Aug;5(8):1676-86.

  124. Eisenhaber F, Frömmel C, Argos P.
    Prediction of secondary structural content of proteins from their amino acid composition alone. II. The paradox with secondary structural class.
    Proteins. 1996 Jun;25(2):169-79.

  125. Eisenhaber F, Imperiale F, Argos P, Frömmel C.
    Prediction of secondary structural content of proteins from their amino acid composition alone. I. New analytic vector decomposition methods.
    Proteins. 1996 Jun;25(2):157-68.

  126. Walther D, Eisenhaber F, Argos P.
    Principles of helix-helix packing in proteins: the helical lattice superposition model.
    J Mol Biol. 1996 Jan 26;255(3):536-53.

  127. Juffer AH, Eisenhaber F, Hubbard SJ, Walther D, Argos P.
    Comparison of atomic solvation parametric sets: applicability and limitations in protein folding and binding.
    Protein Sci. 1995 Dec;4(12):2499-509. Erratum in: Protein Sci 1996 Aug;5(8):1748-9.

  128. Eisenhaber F, Persson B, Argos P.
    Protein structure prediction: recognition of primary, secondary, and tertiary structural features from amino acid sequence.
    Crit Rev Biochem Mol Biol. 1995;30(1):1-94. Review.

  129. Schrauber H, Eisenhaber F, Argos P.
    Rotamers: to be or not to be? An analysis of amino acid side-chain conformations in globular proteins.
    J Mol Biol. 1993 Mar 20;230(2):592-612.

  130. Eisenhaber F, Mannik JH, Tumanyan VG.
    Structural principles of B-DNA grooves hydration in fibers as revealed by Monte Carlo simulations and X-ray diffraction.
    Biopolymers. 1990 Aug 15-Sep;29(10-11):1453-64.

  131. Eisenhaber F, Tumanyan VG, Abagyan RA.
    Structure of the hydration shells of oligo(dA-dT).oligo(dA-dT) and oligo(dA).oligo(dT) tracts in B-type conformation on the basis of Monte Carlo calculations.
    Biopolymers. 1990;30(5-6):563-81.

  132. Eisenhaber F, Tumanyan VG, Eisenmenger F, Gunia W.
    Hydration of B-DNA: comparison between the water network around poly(dG).poly(dC) and poly(dG-dC).poly(dG-dC) on the basis of Monte Carlo computations.
    Biopolymers. 1989 Mar;28(3):741-61.

  133. Eisenhaber F, Tumanian VG.
    [Structure of the hydration envelope of the B-form of polydeoxyribonucleotides poly(dA-dC).poly(dG-dT) and poly(dA-dG).poly(dTs-dT) from the data of Monte-Carlo simulation].
    Biofizika. 1988 May-Jun;33(3):422-9. Russian.


Please contact us by email if you wish a reprint from any of the selected publications.
Feedback Login Site Map