Biography Details
 
Dr. Georg SCHNEIDER
Principal Investigator
 
Areas of Research Interest
 
Georg Schneider's research interest lies in designing and implementing novel tools to predict molecular function and understand biological systems. The field is wide and encompasses methods anchored in information theory, statistical analysis and machine learning. Integrating implementations of these methods makes it possible to explore new heuristics for tracing evolutionary relationships. No sequence analytic system is useful without proper visualization which makes it necessary to keep up-to-date with advances in visualization techniques. Having to come up with robust and flexible systems, he is consequently also interested in software development methodologies and issues of high performance and distributed computing.
 
Biography
 
Georg Schneider was appointed as a Principal Investigator at the Bioinformatics Institute A*STAR Singapore in October 2007, where he leads the ANNOTATOR group which develops tools for functional sequence analysis.

He received a Master from the University of Economics in Vienna, specializing in computer science, and worked as a research associate at the Institute of Applied Informatics using methods from the field of artificial intelligence to design recommender systems and intelligent internet agents. After which he joined Frank Eisenhaber's group at the Institute of Molecular Pathology (IMP), Vienna and obtained a PhD in Chemistry (Bioinformatics) at the Institute of Theoretical Chemistry, Vienna. In his previous position, he was team-leader of the ANNOTATOR development efforts at the IMP.
 
Selected Publications
 
  1. Sirota, FL, Ooi HS, Gattermayer T, Schneider ., Eisenhaber F, Maurer- Stroh S.
    Parameterization of disorder predictors for large-scale applications requiring high specificity by using an extended benchmark dataset.
    BMC Genomics 11, S15 (2010).


  2. Mujezinovic, N., Schneider, G., Wildpaner, M., Mechtler, K. & Eisenhaber,F.
    Reducing the haystack to find the needle: improved protein identification after fast elimination of non-interpretable peptide MS/ MS spectra and noise reduction.
    BMC Genomics 11, S13 (2010).


  3. Ooi,H.S., Schneider,G., Lim,T.-T., Chan,Y.-L., Eisenhaber,B., and Eisenhaber,F. 2009.
    Biomolecular Pathway Databases.
    In Data Mining Techniques for the Life Sciences. O.Carugo, and Eisenhaber,F.E., editors.
    Humana Press and Springer Business Media. New York. 129- 144.


  4. Ooi,H.S., Schneider,G., Chan,Y.-L., Lim,T.-T., Eisenhaber,B., and Eisenhaber,F. 2009.
    Databases of Protein-Protein Interactions and Complexes.
    In Data Mining Techniques for the Life Sciences. O.Carugo, and Eisenhaber,F.E., editors.
    Humana Press and Springer Business Media. New York. 145-160.


  5. Schneider,G., Wildpaner,M., Sirota,F.L., Maurer-Stroh,S., Eisenhaber,B., and Eisenhaber,F. 2009.
    Integrated Tools for Biomolecular Sequence- Based Function Prediction as Exemplified by the ANNOTATOR Software Environment.
    In Data Mining Techniques for the Life Sciences. O. Carugo, and Eisenhaber,F.E., editors.
    Humana Press and Springer Business Media. New York. 257-268.


  6. Ooi HS, Kwo CY, Wildpaner M, Sirota FL, Eisenhaber B, Maurer-Stroh S, Wong WC, Schleiffer A, Eisenhaber F, Schneider G.
    ANNIE: integrated de novo protein sequence annotation.
    Nucleic Acids Res. 2009 Jul 1;37(Web Server issue):W435-440. Epub 2009 Apr 23


  7. Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.
    Towards complete sets of farnesylated and geranylgeranylated proteins.
    PLoS Comput Biol. 2007 Apr 6;3(4):e66. Epub 2007 Feb 23.
    PMID: 17411337 [PubMed - indexed for MEDLINE]


  8. Neuberger G, Schneider G, Eisenhaber F.
    pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model.
    Biol Direct. 2007 Jan 12;2:1.
    PMID: 17222345 [PubMed]


  9. Novatchkova M, Schneider G, Fritz R, Eisenhaber F, Schleiffer A.
    DOUTfinder--identification of distant domain outliers using subsignificant sequence similarity.
    Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W214-8.
    PMID: 16844996 [PubMed - indexed for MEDLINE]


  10. Schneider G, Neuberger G, Wildpaner M, Tian S, Berezovsky I, Eisenhaber F.
    Application of a sensitive collection heuristic for very large protein families: evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases.
    BMC Bioinformatics. 2006 Mar 21;7:164.
    PMID: 16551354 [PubMed - indexed for MEDLINE]


  11. Eisenhaber B, Schneider G, Wildpaner M, Eisenhaber F.
    A sensitive predictor for potential GPI lipid modification sites in fungal protein sequences and its application to genome-wide studies for Aspergillus nidulans, Candida albicans, Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombe.
    J Mol Biol. 2004 Mar 19;337(2):243-53.
    PMID: 15003443 [PubMed - indexed for MEDLINE]


  12. Maurer-Stroh S, Gouda M, Novatchkova M, Schleiffer A, Schneider G, Sirota FL, Wildpaner M, Hayashi N, Eisenhaber F.
    MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins.
    Genome Biol. 2004;5(3):R21. Epub 2004 Feb 13.
    PMID: 15003124 [PubMed - indexed for MEDLINE]


  13. Eisenhaber F, Eisenhaber B, Kubina W, Maurer-Stroh S, Neuberger G, Schneider G, Wildpaner M.
    Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1.
    Nucleic Acids Res. 2003 Jul 1;31(13):3631-4.
    PMID: 12824382 [PubMed - indexed for MEDLINE]


  14. Wick N, Luedemann S, Vietor I, Cotten M, Wildpaner M, Schneider G, Eisenhaber F, Huber LA.
    Induction of short interspersed nuclear repeat-containing transcripts in epithelial cells upon infection with a chicken adenovirus.
    J Mol Biol. 2003 May 9;328(4):779-90.
    PMID: 12729754 [PubMed - indexed for MEDLINE]


  15. Eisenhaber B, Maurer-Stroh S, Novatchkova M, Schneider G, Eisenhaber F.
    Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins.
    Bioessays. 2003 Apr;25(4):367-85. Review.
    PMID: 12655644 [PubMed - indexed for MEDLINE]


  16. Wildpaner M, Schneider G, Schleiffer A, Eisenhaber F.
    Taxonomy workbench.
    Bioinformatics. 2001 Dec;17(12):1179-82.
    PMID: 11751226 [PubMed - indexed for MEDLINE]
 

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