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  Biography Details
 
Dr. Sebastian MAURER-STROH
Principal Investigator
 
Areas of Research Interest
 
Sebastian Maurer-Stroh's research interests lies in mapping the uncharted islands in functional protein sequence space. This includes inferring functions for uncharacterized genes/proteins based on remote evolutionary relationships, prediction of the 3-dimensional structure of proteins, identification of biologically important residues and disease-related mutations, as well as developing predictors for short functional motifs in protein sequences.
 
Biography
 
Sebastian Maurer-Stroh studied theoretical biochemistry at the University of Vienna and wrote his master and PhD thesis at the renowned Institute of Molecular Pathology (IMP). After the honour of a FEBS and a Marie Curie fellowship at the VIB-SWITCH lab in Brussels, he leads a group of experts in protein sequence analysis as principal investigator in the A*STAR Bioinformatics Institute (BII) since November 2007. He has contributed widely used predictors for posttranslational lipid modifications, amyloid fibre formation and catalyzed new biomedical insights by sequence-based function predictions. He has been at the forefront of research during the 2009 H1N1 pandemic collaborating with hospitals and health authorities in Singapore, Mexico, Brazil and Australia. He initiated a cross-division programme for Human Infectious Diseases at the Bioinformatics Institute that builds upon the expertise of several groups from different backgrounds and expands the range of human pathogens studied at BII.
 
Selected Publications
 
  1. Hurt A, Lee R, Leang S, Cui L, Deng Y, Phuah S, Caldwell N, Freeman K, Komadina N, Smith D, Speers D, Kelso A, Lin R, Maurer-Stroh S, Barr I.
    Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation.
    2011 Jun 9;16(23). pii: 19884.
    PubMed PMID: 21679678


  2. Wong WC, Maurer-Stroh S, Eisenhaber F.
    The Janus-faced E-values of HMMER2: extreme value distribution or logistic function?
    J Bioinform Comput Biol. 2011 Feb;9(1):179-206.
    PubMed PMID: 21328712


  3. Toh YK, Kamariah N, Maurer-Stroh S, Roessle M, Eisenhaber F, Adhikari S, Eisenhaber B, Grüber G.
    Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast.
    J Struct Biol. 2011 Feb;173(2):271-81. Epub 2010 Dec 4.
    PubMed PMID: 21134462


  4. Lee VJ, Yap J, Maurer-Stroh S, Lee RT, Eisenhaber F, Tay JK, Ting PJ, Loh JP, Wong CW, Tan BH, Koay ES, Kelly PM, Hibberd ML
    Investigation of causes of oseltamivir chemoprophylaxis failures during influenza A (H1N1-2009) outbreaks.
    J Clin Virol. 2011 Feb;50(2):104-8. Epub 2010 Nov 19
    PubMed PMID: 21094080


  5. Lee RT, Santos CL, de Paiva TM, Cui L, Sirota FL, Eisenhaber F, Maurer-Stroh S.
    All that glitters is not gold--founder effects complicate associations of flu mutations to disease severity.
    Virol J. 2010 Nov 1;7:297
    PubMed PMID: 21040570; PubMed Central PMCID: PMC2989967


  6. Barr IG, Cui L, Komadina N, Lee RT, Lin RT, Deng Y, Caldwell N, Shaw R, Maurer-Stroh S.
    A new pandemic influenza A(H1N1) genetic variant predominated in the winter 2010 influenza season in Australia, New Zealand and Singapore.
    Euro Surveill. 2010 Oct 21;15(42). pii: 19692.
    PubMed PMID: 21034722


  7. Maurer-Stroh S, Paing SS, Lee RT, Eisenhaber F.
    Sporadic human cases of swine-origin influenza before 2009 share the Sa epitope.
    Cell Cycle. 2010 Sep 15;9(18):3826-8. Epub 2010 Sep 26.
    PubMed PMID: 20930526; PubMed Central PMCID: PMC3047805.


  8. Inoue M, Barkham T, Leo YS, Chan KP, Chow A, Wong CW, Tze Chuen Lee R, Maurer-Stroh S, Lin R, Lin C.
    Emergence of oseltamivir-resistant pandemic (H1N1) 2009 virus within 48 hours.
    Emerg Infect Dis. 2010 Oct;16(10):1633-6.
    PubMed PMID: 20875299.


  9. Limviphuvadh V, Chua LL, Rahim RA, Eisenhaber F, Maurer-Stroh S, Adhikari S.
    Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2.
    BMC Biochem. 2010 Sep 24;11:39.
    PubMed PMID: 20863412. PubMed Central PMCID: PMC2949613.


  10. Wong WC, Maurer-Stroh S, Eisenhaber F.
    More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology.
    PLoS Comput Biol. 2010 Jul 29;6(7):e1000867.
    PubMed PMID: 20686689; PubMed Central PMCID: PMC2912341.


  11. Ahmed S, Bu W, Lee RT, Maurer-Stroh S, Goh WI
    F-BAR domain proteins: Families and function.
    Commun Integr Biol. 2010 Mar;3(2):116-21.
    PubMed PMID: 20585502; PubMed Central PMCID: PMC2889966.


  12. Van Damme P, Maurer-Stroh S, Hao H, Colaert N, Timmerman E, Eisenhaber F, Vandekerckhove J, Gevaert K
    The substrate specificity profile of human granzyme A
    Biol Chem. 2010 Aug;391(8):983-97.
    PubMed PMID: 20536382.


  13. Maurer-Stroh S, Lee RT, Eisenhaber F, Cui L, Phuah SP, Lin RT.
    A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus.
    PLoS Curr. 2010 Jun 1;2:RRN1162.
    PubMed PMID: 20535229; PubMed Central PMCID: PMC2880458.


  14. Schneider G, Wildpaner M, Sirota FL, Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    Integrated tools for biomolecular sequence-based function prediction as exemplified by the ANNOTATOR software environment.
    Methods Mol Biol. 2010;609:257-67.
    PubMed PMID: 20221924.


  15. Sirota FL, Ooi HS, Gattermayer T, Schneider G, Eisenhaber F, Maurer-Stroh S.
    Parameterization of disorder predictors for large-scale applications requiring high specificity by using an extended benchmark dataset.
    BMC Genomics. 2010 Feb 10;11 Suppl 1:S15.
    PubMed PMID: 20158872; PubMed Central PMCID: PMC2822529.


  16. Limviphuvadh V, Chua LL, Eisenhaber F, Adhikari S, Maurer-Stroh S.
    Is LGI2 the candidate gene for partial epilepsy with pericentral spikes?
    J Bioinform Comput Biol. 2010 Feb;8(1):117-27.
    PubMed PMID: 20183877.


  17. Maurer-Stroh S, Debulpaep M, Kuemmerer N, Lopez de la Paz M, Martins IC, Reumers J, Morris KL, Copland A, Serpell L, Serrano L, Schymkowitz JW, Rousseau F.
    Exploring the sequence determinants of amyloid structure using position-specific scoring matrices.
    Nat Methods. 2010 Mar;7(3):237-42. Epub 2010 Feb 14.
    PubMed PMID: 20154676.


  18. Kawase-Koga Y, Low R, Otaegi G, Pollock A, Deng H, Eisenhaber F, Maurer-Stroh S, Sun T.
    RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells.
    J Cell Sci. 2010 Feb 15;123(Pt 4):586-94. Epub 2010 Jan 26.
    PubMed PMID: 20103535; PubMed Central PMCID: PMC2818196.


  19. Van Durme J, Maurer-Stroh S, Gallardo R, Wilkinson H, Rousseau F, Schymkowitz J.
    Accurate prediction of DnaK-peptide binding via homology modelling and experimental data.
    PLoS Comput Biol. 2009 Aug;5(8):e1000475. Epub 2009 Aug 21.
    PubMed PMID: 19696878; PubMed Central PMCID: PMC2717214.


  20. Maurer-Stroh S, Ma J, Lee RT, Sirota FL, Eisenhaber F.
    Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites.
    Biol Direct. 2009 May 20;4:18; discussion 18.
    PubMed PMID: 19457254; PubMed Central PMCID: PMC2691737.


  21. Ooi HS, Kwo CY, Wildpaner M, Sirota FL, Eisenhaber B, Maurer-Stroh S, Wong WC, Schleiffer A, Eisenhaber F, Schneider G.
    ANNIE: integrated de novo protein sequence annotation.
    Nucleic Acids Res. 2009 Jul 1;37(Web Server issue):W435-40. Epub 2009 Apr 23.
    PubMed PMID: 19389726; PubMed Central PMCID: PMC2703921.


  22. Dhar PK, Thwin CS, Tun K, Tsumoto Y, Maurer-Stroh S, Eisenhaber F, Surana U.
    Synthesizing non-natural parts from natural genomic template.
    J Biol Eng. 2009 Feb 3;3:2.
    PubMed PMID: 19187561; PubMed Central PMCID: PMC2642765.


  23. Reumers J, Maurer-Stroh S, Schymkowitz J, Rousseau F.
    Protein sequences encode safeguards against aggregation.
    Hum Mutat. 2009 Mar;30(3):431-7.
    PubMed PMID: 19156839.


  24. Benetka W, Mehlmer N, Maurer-Stroh S, Sammer M, Koranda M, Neumüller R, Betschinger J, Knoblich JA, Teige M, Eisenhaber F.
    Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling.
    Cell Cycle. 2008 Dec;7(23):3709-19. Epub 2008 Dec 13. Erratum in: Cell Cycle. 2009 Feb 1;8(3):508-9.
    PubMed PMID: 19029837.


  25. Van Damme P, Maurer-Stroh S, Plasman K, Van Durme J, Colaert N, Timmerman E, De Bock PJ, Goethals M, Rousseau F, Schymkowitz J, Vandekerckhove J, Gevaert K.
    Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs.
    Mol Cell Proteomics. 2009 Feb;8(2):258-72. Epub 2008 Oct 3.
    PubMed PMID: 18836177.


  26. Brouwers N, Sleegers K, Engelborghs S, Maurer-Stroh S, Gijselinck I, van der Zee J, Pickut BA, Van den Broeck M, Mattheijssens M, Peeters K, Schymkowitz J, Rousseau F, Martin JJ, Cruts M, De Deyn PP, Van Broeckhoven C.
    Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.
    Neurology. 2008 Aug 26;71(9):656-64. Epub 2008 Jun 18.
    PubMed PMID: 18565828.


  27. Sirota FL, Héry-Huynh S, Maurer-Stroh S, Wodak SJ.
    Role of the amino acid sequence in domain swapping of the B1 domain of protein G.
    Proteins. 2008 Jul;72(1):88-104.
    PubMed PMID: 18186476.


  28. Sleegers K, Brouwers N, Maurer-Stroh S, van Es MA, Van Damme P, van Vught PW, van der Zee J, Serneels S, De Pooter T, Van den Broeck M, Cruts M, Schymkowitz J, De Jonghe P, Rousseau F, van den Berg LH, Robberecht W, Van Broeckhoven C.
    Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
    Neurology. 2008 Jul 22;71(4):253-9. Epub 2008 Jan 9.
    PubMed PMID: 18184915.


  29. Reumers J, Conde L, Medina I, Maurer-Stroh S, Van Durme J, Dopazo J, Rousseau F, Schymkowitz J.
    Joint annotation of coding and non-coding single nucleotide polymorphisms and mutations in the SNPeffect and PupaSuite databases.
    Nucleic Acids Res. 2008 Jan;36(Database issue):D825-9. Epub 2007 Dec 17.
    PubMed PMID: 18086700; PubMed Central PMCID: PMC2238831.


  30. Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.
    Towards complete sets of farnesylated and geranylgeranylated proteins.
    PLoS Comput Biol. 2007 Apr 6;3(4):e66. Epub 2007 Feb 23.
    PubMed PMID: 17411337; PubMed Central PMCID: PMC1847700.


  31. van der Zee J, Le Ber I, Maurer-Stroh S, Engelborghs S, Gijselinck I, Camuzat A, Brouwers N, Vandenberghe R, Sleegers K, Hannequin D, Dermaut B, Schymkowitz J, Campion D, Santens P, Martin JJ, Lacomblez L, De Pooter T, Peeters K, Mattheijssens M, Vercelletto M, Van den Broeck M, Cruts M, De Deyn PP, Rousseau F, Brice A, Van Broeckhoven C.
    Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
    Hum Mutat. 2007 Apr;28(4):416.
    PubMed PMID: 17345602.


  32. Reumers J, Maurer-Stroh S, Schymkowitz J, Rousseau F.
    SNPeffect v2.0: a new step in investigating the molecular phenotypic effects of human non-synonymous SNPs.
    Bioinformatics. 2006 Sep 1;22(17):2183-5. Epub 2006 Jun 29.
    PubMed PMID: 16809394.


  33. Benetka W, Koranda M, Maurer-Stroh S, Pittner F, Eisenhaber F.
    Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo.
    BMC Biochem. 2006 Feb 28;7:6.
    PubMed PMID: 16507103; PubMed Central PMCID: PMC1448197.


  34. Maurer-Stroh S, Eisenhaber F
    Refinement and prediction of protein prenylation motifs.
    Genome Biol. 2005;6(6):R55. Epub 2005 May 27.
    PubMed PMID: 15960807; PubMed Central PMCID: PMC1175975.


  35. Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM.
    The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.
    Mol Cell. 2005 May 27;18(5):543-53.
    PubMed PMID: 15916961.


  36. Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T.
    Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes.
    Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10984-9. Epub 2004 Jul 19.
    PubMed PMID: 15263099; PubMed Central PMCID: PMC503730.


  37. Eisenhaber B, Eisenhaber F, Maurer-Stroh S, Neuberger G.
    Prediction of sequence signals for lipid post-translational modifications: insights from case studies.
    Proteomics. 2004 Jun;4(6):1614-25.
    PubMed PMID: 15174131.


  38. Maurer-Stroh S, Eisenhaber F.
    Myristoylation of viral and bacterial proteins.
    Trends Microbiol. 2004 Apr;12(4):178-85. Review.
    PubMed PMID: 15051068.


  39. Maurer-Stroh S, Gouda M, Novatchkova M, Schleiffer A, Schneider G, Sirota FL, Wildpaner M, Hayashi N, Eisenhaber F.
    MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins.
    Genome Biol. 2004;5(3):R21. Epub 2004 Feb 13.
    PubMed PMID: 15003124; PubMed Central PMCID: PMC395771.


  40. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM.
    TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.
    Curr Biol. 2003 Sep 2;13(17):1459-68.
    PubMed PMID: 12956947.


  41. Maurer-Stroh S, Washietl S, Eisenhaber F.
    Protein prenyltransferases: anchor size, pseudogenes and parasites.
    Biol Chem. 2003 Jul;384(7):977-89. Review.
    PubMed PMID: 12956414.


  42. Eisenhaber F, Eisenhaber B, Kubina W, Maurer-Stroh S, Neuberger G, Schneider G, Wildpaner M.
    Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1.
    Nucleic Acids Res. 2003 Jul 1;31(13):3631-4.
    PubMed PMID: 12824382; PubMed Central PMCID: PMC168944.


  43. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence.
    J Mol Biol. 2003 May 2;328(3):581-92.
    PubMed PMID: 12706718.


  44. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences.
    J Mol Biol. 2003 May 2;328(3):567-79.
    PubMed PMID: 12706717.


  45. Maurer-Stroh S, Washietl S, Eisenhaber F.
    Protein prenyltransferases.
    Genome Biol. 2003;4(4):212. Epub 2003 Apr 1. Review.
    PubMed PMID: 12702202; PubMed Central PMCID: PMC154572.


  46. Schleiffer A, Kaitna S, Maurer-Stroh S, Glotzer M, Nasmyth K, Eisenhaber F.
    Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
    Mol Cell. 2003 Mar;11(3):571-5.
    PubMed PMID: 12667442.


  47. Eisenhaber B, Maurer-Stroh S, Novatchkova M, Schneider G, Eisenhaber F.
    Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins.
    Bioessays. 2003 Apr;25(4):367-85. Review.
    PubMed PMID: 12655644.


  48. Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F.
    Ponting CP. The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
    Trends Biochem Sci. 2003 Feb;28(2):69-74.
    PubMed PMID: 12575993.


  49. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence.
    J Mol Biol. 2002 Apr 5;317(4):541-57.
    PubMed PMID: 11955008.


  50. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences.
    J Mol Biol. 2002 Apr 5;317(4):523-40.
    PubMed PMID: 11955007.


  51. Flamm C, Hofacker IL, Maurer-Stroh S, Stadler PF, Zehl M.
    Design of multistable RNA molecules.
    RNA. 2001 Feb;7(2):254-65.
    PubMed PMID: 11233982; PubMed Central PMCID: PMC1370083
 

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