Biography Details
 
Dr. MAURER-STROH Sebastian
Senior Principal Investigator
 
Areas of Research Interest
 
Sebastian Maurer-Stroh's research interests lies in mapping the uncharted islands in functional protein sequence space. This includes inferring functions for uncharacterized genes/proteins based on remote evolutionary relationships, prediction of the 3-dimensional structure of proteins, identification of biologically important residues and disease-related mutations, as well as developing predictors for short functional motifs in protein sequences.
 
Biography
 
Sebastian Maurer-Stroh studied theoretical biochemistry at the University of Vienna and wrote his master and PhD thesis at the renowned Institute of Molecular Pathology (IMP). After the honour of a FEBS and a Marie Curie fellowship at the VIB-SWITCH lab in Brussels, he leads a group of experts in protein sequence analysis as a senior principal investigator in the A*STAR Bioinformatics Institute (BII) since November 2007. He has contributed widely used predictors for posttranslational lipid modifications, amyloid fibre formation and catalyzed new biomedical insights by sequence-based function predictions. He has been at the forefront of research during the 2009 H1N1 pandemic collaborating with hospitals and health authorities in Singapore, Mexico, Brazil and Australia. He initiated a cross-division programme for Human Infectious Diseases at the Bioinformatics Institute that builds upon the expertise of several groups from different backgrounds and expands the range of human pathogens studied at BII.
 
Selected Publications
 
  1. Joseph U, Linster M, Suzuki Y, Krauss S, Halpin RA, Vijaykrishna D, Fabrizio TP, Bestebroer TM, Maurer-Stroh S, Webby RJ, Wentworth DE, Fouchier RA, Bahl J, Smith GJ.
    Adaptation of Pandemic H2N2 Influenza A Viruses in Humans.
    J Virol. 2015 Feb 15;89(4):2442-7. doi: 10.1128/JVI.02590-14. Epub 2014 Dec 10.

  2. Ho ZJ, Vithia G, Ng CG, Maurer-Stroh S, Tan CM, Loh J, Lin TP, Lee JM.
    Emergence of norovirus GI.2 outbreaks in military camps in Singapore.
    Int J Infect Dis. 2015 Feb;31:23-30. doi: 10.1016/j.ijid.2014.12.023. Epub 2014 Dec 18.

  3. Vijaykrishna D, Holmes EC, Joseph U, Fourment M, Su YC, Halpin R, Lee RT, Deng YM, Gunalan V, Lin X, Stockwell TB, Fedorova NB, Zhou B, Spirason N, Kühnert D, Boskova V, Stadler T, Costa AM, Dwyer DE, Huang QS, Jennings LC, Rawlinson W, Sullivan SG, Hurt AC, Maurer-Stroh S, Wentworth DE, Smith GJ, Barr I.
    The contrasting phylodynamics of human influenza B viruses.
    Elife. 2015 Jan 16;4. doi: 10.7554/eLife.05055. [Epub ahead of print]

  4. Kunze M, Malkani N, Maurer-Stroh S, Wiesinger C, Schmid JA, Berger J.
    Mechanistic Insights into PTS2-mediated Peroxisomal Protein Import: The Co-receptor PEX5L drastically increases the Interaction Strength between the Cargo Protein and the Receptor PEX7.
    J Biol Chem. 2014 Dec 23. pii: jbc.M114.601575. [Epub ahead of print]

  5. Mah T, Yap X, Limviphuvadh V, Li N, Sridharan S, Kuralmani V, Feng M, Liem N, Adhikari S, Yong W, Soo RA, Maurer-Stroh S, Eisenhaber F, Tong J.
    Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.
    BMC Genomics. 2014 Dec 8;15 Suppl 9:S20. doi: 10.1186/1471-2164-15-S9-S20. Epub 2014 Dec 8.

  6. Ponomarenko J, Vaughan K, Sette A, Maurer-Stroh S.
    Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks.
    PLoS Curr. 2014 Nov 3;6. pii: ecurrents.outbreaks.f1a7028a13ce1c5f0bdbb4b0cc0b919b. doi: 10.1371/currents.outbreaks.f1a7028a13ce1c5f0bdbb4b0cc0b919b.

  7. Russell CA, Kasson PM, Donis RO, Riley S, Dunbar J, Rambaut A, Asher J, Burke S, Davis CT, Garten RJ, Gnanakaran S, Hay SI, Herfst S, Lewis NS, Lloyd-Smith JO, Macken CA, Maurer-Stroh S, Neuhaus E, Parrish CR, Pepin KM, Shepard SS, Smith DL, Suarez DL, Trock SC, Widdowson MA, George DB, Lipsitch M, Bloom JD.
    Improving pandemic influenza risk assessment.
    Elife. 2014 Oct 16;3:e03883. doi: 10.7554/eLife.03883.

  8. Thi TH, Wang L, Ye N, Zhang J, Maurer-Stroh S, Cheng L.
    Recognizing flu-like symptoms from videos.
    BMC Bioinformatics. 2014 Sep 12;15:300. doi: 10.1186/1471-2105-15-300.

  9. Van Damme P, Plasman K, Vandemoortele G, Jonckheere V, Maurer-Stroh S, Gevaert K.
    Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B.
    BMC Biochem. 2014 Sep 10;15:21. doi: 10.1186/1471-2091-15-21.

  10. Low JG, Lee LS, Ooi EE, Ethirajulu K, Yeo P, Matter A, Connolly JE, Skibinski DA, Saudan P, Bachmann M, Hanson BJ, Lu Q, Maurer-Stroh S, Lim S, Novotny-Diermayr V.
    Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers.
    Vaccine. 2014 Sep 3;32(39):5041-8. doi: 10.1016/j.vaccine.2014.07.011. Epub 2014 Jul 18.

  11. Maurer-Stroh S, Li Y, Bastien N, Gunalan V, Lee RT, Eisenhaber F, Booth TF.
    Potential human adaptation mutation of influenza A(H5N1) virus, Canada.
    Emerg Infect Dis. 2014 Sep;20(9):1580-2. doi: 10.3201/eid2009.140240. No abstract available.

  12. Hauser CA, Maurer-Stroh S, Martins IC.
    Amyloid-based nanosensors and nanodevices.
    Chem Soc Rev. 2014 Aug 7;43(15):5326-45. doi: 10.1039/c4cs00082j.

  13. Wong WC, Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation.
    BMC Bioinformatics. 2014 Jun 2;15:166. doi: 10.1186/1471-2105-15-166.

  14. Hurt AC, Vijaykrishna D, Butler J, Baas C, Maurer-Stroh S, Silva-de-la-Fuente MC, Medina-Vogel G, Olsen B, Kelso A, Barr IG, González-Acuña D.
    Detection of evolutionarily distinct avian influenza a viruses in antarctica.
    MBio. 2014 May 6;5(3):e01098-14. doi: 10.1128/mBio.01098-14.

  15. Plasman K, Maurer-Stroh S, Gevaert K, Van Damme P.
    Holistic view on the extended substrate specificities of orthologous granzymes.
    J Proteome Res. 2014 Apr 4;13(4):1785-93. doi: 10.1021/pr401104b. Epub 2014 Mar 10. Review.

  16. Butler J, Hooper KA, Petrie S, Lee R, Maurer-Stroh S, Reh L, Guarnaccia T, Baas C, Xue L, Vitesnik S, Leang SK, McVernon J, Kelso A, Barr IG, McCaw JM, Bloom JD, Hurt AC.
    Estimating the fitness advantage conferred by permissive neuraminidase mutations in recent oseltamivir-resistant A(H1N1)pdm09 influenza viruses.
    PLoS Pathog. 2014 Apr 3;10(4):e1004065. doi: 10.1371/journal.ppat.1004065. eCollection 2014 Apr.

  17. Tate MD, Job ER, Deng YM, Gunalan V, Maurer-Stroh S, Reading PC.
    Playing hide and seek: how glycosylation of the influenza virus hemagglutinin can modulate the immune response to infection.
    Viruses. 2014 Mar 14;6(3):1294-316. doi: 10.3390/v6031294. Review.

  18. Leang SK, Kwok S, Sullivan SG, Maurer-Stroh S, Kelso A, Barr IG, Hurt AC.
    Peramivir and laninamivir susceptibility of circulating influenza A and B viruses.
    Influenza Other Respir Viruses. 2014 Mar;8(2):135-9.

  19. Joshi A, Lee RT, Mohl J, Sedano M, Khong WX, Ng OT, Maurer-Stroh S, Garg H.
    Genetic signatures of HIV-1 envelope-mediated bystander apoptosis.
    J Biol Chem. 2014 Jan 31;289(5):2497-514. doi: 10.1074/jbc.M113.514018. Epub 2013 Nov 21.

  20. Ma J, Eisenhaber F, Maurer-Stroh S.
    Automatic phylogenetic classification of bacterial beta-lactamase sequences including structural and antibiotic substrate preference information.
    J Bioinform Comput Biol. 2013 Dec;11(6):1343011. doi: 10.1142/S0219720013430117. Epub 2013 Dec 11.

  21. Maurer-Stroh S, Gunalan V, Wong WC, Eisenhaber F.
    A simple shortcut to unsupervised alignment-free phylogenetic genome groupings, even from unassembled sequencing reads.
    J Bioinform Comput Biol. 2013 Dec;11(6):1343005. doi: 10.1142/S0219720013430051. Epub 2013 Dec 2.

  22. Lee RT, Gunalan V, Van TD, Le LT, Eisenhaber F, Maurer-Stroh S.
    A new piece in the puzzle of the novel avian-origin influenza A (H7N9) virus.
    Biol Direct. 2013 Oct 26;8:26. doi: 10.1186/1745-6150-8-26.

  23. Plasman K, Maurer-Stroh S, Ahmad J, Hao H, Kaiserman D, Sirota FL, Jonckheere V, Bird PI, Gevaert K, Van Damme P.
    Conservation of the extended substrate specificity profiles among homologous granzymes across species.
    Mol Cell Proteomics. 2013 Oct;12(10):2921-34. doi: 10.1074/mcp.M113.028670. Epub 2013 Jun 20.

  24. Garg H, Lee RT, Tek NO, Maurer-Stroh S, Joshi A.
    Identification of conserved motifs in the West Nile virus envelope essential for particle secretion.
    BMC Microbiol. 2013 Sep 4;13:197. doi: 10.1186/1471-2180-13-197.

  25. Tran-Viet KN, Powell C, Barathi VA, Klemm T, Maurer-Stroh S, Limviphuvadh V, Soler V, Ho C, Yanovitch T, Schneider G, Li YJ, Nading E, Metlapally R, Saw SM, Goh L, Rozen S, Young TL.
    Mutations in SCO2 are associated with autosomal-dominant high-grade myopia.
    Am J Hum Genet. 2013 May 2;92(5):820-6. doi: 10.1016/j.ajhg.2013.04.005.

  26. Maurer-Stroh S, Lee RT, Gunalan V, Eisenhaber F.
    The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA.
    Virol J. 2013 May 1;10:139. doi: 10.1186/1743-422X-10-139.

  27. Soler VJ, Tran-Viet KN, Galiacy SD, Limviphuvadh V, Klemm TP, St Germain E, Fournié PR, Guillaud C, Maurer-Stroh S, Hawthorne F, Suarez C, Kantelip B, Afshari NA, Creveaux I, Luo X, Meng W, Calvas P, Cassagne M, Arné JL, Rozen SG, Malecaze F, Young TL.
    Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis.
    J Med Genet. 2013 Apr;50(4):246-54. doi: 10.1136/jmedgenet-2012-101325. Epub 2013 Jan 24.

  28. Simoes EA, Patel C, Sung WK, Lee CW, Loh KH, Lucero M, Nohynek H, Nai G, Thien PL, Koh CW, Chan YS, Ma J, Maurer-Stroh S, Carosone-Link P, Hibberd ML, Wong CW; ARIVAC Consortium.
    Pathogen chip for respiratory tract infections.
    J Clin Microbiol. 2013 Mar;51(3):945-53. doi: 10.1128/JCM.02317-12. Epub 2013 Jan 9.

  29. Job ER, Deng YM, Barfod KK, Tate MD, Caldwell N, Reddiex S, Maurer-Stroh S, Brooks AG, Reading PC.
    Addition of glycosylation to influenza A virus hemagglutinin modulates antibody-mediated recognition of H1N1 2009 pandemic viruses.
    J Immunol. 2013 Mar 1;190(5):2169-77. doi: 10.4049/jimmunol.1202433. Epub 2013 Jan 30.

  30. Maurer-Stroh S, Gao H, Han H, Baeten L, Schymkowitz J, Rousseau F, Zhang L, Eisenhaber F.
    Motif discovery with data mining in 3D protein structure databases: discovery, validation and prediction of the U-shape zinc binding ("Huf-Zinc") motif.
    J Bioinform Comput Biol. 2013 Feb;11(1):1340008. doi: 10.1142/S0219720013400088. Epub 2013 Jan 16.

  31. Guarnaccia T, Carolan LA, Maurer-Stroh S, Lee RT, Job E, Reading PC, Petrie S, McCaw JM, McVernon J, Hurt AC, Kelso A, Mosse J, Barr IG, Laurie KL.
    Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model.
    PLoS Pathog. 2013;9(5):e1003354. doi: 10.1371/journal.ppat.1003354. Epub 2013 May 9.

  32. Sirota FL, Batagov A, Schneider G, Eisenhaber B, Eisenhaber F, Maurer-Stroh S.
    Beware of moving targets: reference proteome content fluctuates substantially over the years.
    J Bioinform Comput Biol. 2012 Dec;10(6):1250020. doi: 10.1142/S0219720012500205. Epub 2012 Aug 7.

  33. Xu J, Lim SB, Ng MY, Ali SM, Kausalya JP, Limviphuvadh V, Maurer-Stroh S, Hunziker W.
    ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells.
    Stem Cells. 2012 Sep;30(9):1885-900. doi: 10.1002/stem.1172.

  34. Hurt AC, Hardie K, Wilson NJ, Deng YM, Osbourn M, Leang SK, Lee RT, Iannello P, Gehrig N, Shaw R, Wark P, Caldwell N, Givney RC, Xue L, Maurer-Stroh S, Dwyer DE, Wang B, Smith DW, Levy A, Booy R, Dixit R, Merritt T, Kelso A, Dalton C, Durrheim D, Barr IG.
    Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia.
    J Infect Dis. 2012 Jul 15;206(2):148-57. doi: 10.1093/infdis/jis337. Epub 2012 May 4.

  35. Wong WC, Maurer-Stroh S, Schneider G, Eisenhaber F.
    Transmembrane helix: simple or complex.
    Nucleic Acids Res. 2012 Jul;40(Web Server issue):W370-5. doi: 10.1093/nar/gks379. Epub 2012 May 7.

  36. Tan J, Kuchibhatla D, Sirota FL, Sherman WA, Gattermayer T, Kwoh CY, Eisenhaber F, Schneider G, Maurer-Stroh S.
    Tachyon search speeds up retrieval of similar sequences by several orders of magnitude.
    Bioinformatics. 2012 Jun 15;28(12):1645-6. doi: 10.1093/bioinformatics/bts197. Epub 2012 Apr 23.

  37. Hurt AC, Leang SK, Speers DJ, Barr IG, Maurer-Stroh S.
    Mutations I117V and I117M and oseltamivir sensitivity of pandemic (H1N1) 2009 viruses.
    Emerg Infect Dis. 2012 Jan;18(1):109-12. doi: 10.3201/eid1801.111079.

  38. De Baets G, Van Durme J, Reumers J, Maurer-Stroh S, Vanhee P, Dopazo J, Schymkowitz J, Rousseau F.
    SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants.
    Nucleic Acids Res. 2012 Jan;40(Database issue):D935-9. doi: 10.1093/nar/gkr996. Epub 2011 Nov 10.

  39. Kunze M, Neuberger G, Maurer-Stroh S, Ma J, Eck T, Braverman N, Schmid JA, Eisenhaber F, Berger J.
    Structural requirements for interaction of peroxisomal targeting signal 2 and its receptor PEX7.
    J Biol Chem. 2011 Dec 30;286(52):45048-62. doi: 10.1074/jbc.M111.301853. Epub 2011 Nov 5.

  40. Wong WC, Maurer-Stroh S, Eisenhaber F.
    Not all transmembrane helices are born equal: Towards the extension of the sequence homology concept to membrane proteins.
    Biol Direct. 2011 Oct 25;6:57. doi: 10.1186/1745-6150-6-57.

  41. Hurt AC, Lee RT, Leang SK, Cui L, Deng YM, Phuah SP, Caldwell N, Freeman K, Komadina N, Smith D, Speers D, Kelso A, Lin RT, Maurer-Stroh S, Barr IG.
    Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation.
    Euro Surveill. 2011 Jun 9;16(23). pii: 19884. Erratum in: Euro Surveill. 2011;16(27). pii: 19909.

  42. Wong WC, Maurer-Stroh S, Eisenhaber F.
    The Janus-faced E-values of HMMER2: extreme value distribution or logistic function?
    J Bioinform Comput Biol. 2011 Feb;9(1):179-206.

  43. Lee VJ, Yap J, Maurer-Stroh S, Lee RT, Eisenhaber F, Tay JK, Ting PJ, Loh JP, Wong CW, Tan BH, Koay ES, Kelly PM, Hibberd ML.
    Investigation of causes of oseltamivir chemoprophylaxis failures during influenza A (H1N1-2009) outbreaks.
    J Clin Virol. 2011 Feb;50(2):104-8. doi: 10.1016/j.jcv.2010.10.004. Epub 2010 Nov 19.

  44. Toh YK, Kamariah N, Maurer-Stroh S, Roessle M, Eisenhaber F, Adhikari S, Eisenhaber B, Grüber G.
    Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast.
    J Struct Biol. 2011 Feb;173(2):271-81. doi: 10.1016/j.jsb.2010.11.026. Epub 2010 Dec 4.

  45. Lee RT, Santos CL, de Paiva TM, Cui L, Sirota FL, Eisenhaber F, Maurer-Stroh S.
    All that glitters is not gold--founder effects complicate associations of flu mutations to disease severity.
    Virol J. 2010 Nov 1;7:297. doi: 10.1186/1743-422X-7-297.

  46. Barr IG, Cui L, Komadina N, Lee RT, Lin RT, Deng Y, Caldwell N, Shaw R, Maurer-Stroh S.
    A new pandemic influenza A(H1N1) genetic variant predominated in the winter 2010 influenza season in Australia, New Zealand and Singapore.
    Euro Surveill. 2010 Oct 21;15(42). pii: 19692.

  47. Inoue M, Barkham T, Leo YS, Chan KP, Chow A, Wong CW, Tze Chuen Lee R, Maurer-Stroh S, Lin R, Lin C.
    Emergence of oseltamivir-resistant pandemic (H1N1) 2009 virus within 48 hours.
    Emerg Infect Dis. 2010 Oct;16(10):1633-6. doi: 10.3201/eid1610.100688.

  48. Limviphuvadh V, Chua LL, Rahim RA, Eisenhaber F, Maurer-Stroh S, Adhikari S.
    Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2.
    BMC Biochem. 2010 Sep 24;11:39. doi: 10.1186/1471-2091-11-39.

  49. Maurer-Stroh S, Paing SS, Lee RT, Eisenhaber F.
    Sporadic human cases of swine-origin influenza before 2009 share the Sa epitope.
    Cell Cycle. 2010 Sep 15;9(18):3826-8. doi: 10.4161/cc.9.18.13166. Epub 2010 Sep 26. No abstract available.

  50. Van Damme P, Maurer-Stroh S, Hao H, Colaert N, Timmerman E, Eisenhaber F, Vandekerckhove J, Gevaert K.
    The substrate specificity profile of human granzyme A.
    Biol Chem. 2010 Aug;391(8):983-97. doi: 10.1515/BC.2010.096.

  51. Wong WC, Maurer-Stroh S, Eisenhaber F.
    More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology.
    PLoS Comput Biol. 2010 Jul 29;6(7):e1000867. doi: 10.1371/journal.pcbi.1000867.

  52. Maurer-Stroh S, Lee RT, Eisenhaber F, Cui L, Phuah SP, Lin RT.
    A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus.
    PLoS Curr. 2010 Jun 1;2:RRN1162.

  53. Ahmed S, Bu W, Lee RT, Maurer-Stroh S, Goh WI.
    F-BAR domain proteins: Families and function.
    Commun Integr Biol. 2010 Mar;3(2):116-21.

  54. Maurer-Stroh S, Debulpaep M, Kuemmerer N, Lopez de la Paz M, Martins IC, Reumers J, Morris KL, Copland A, Serpell L, Serrano L, Schymkowitz JW, Rousseau F.
    Exploring the sequence determinants of amyloid structure using position-specific scoring matrices.
    Nat Methods. 2010 Mar;7(3):237-42. doi: 10.1038/nmeth.1432. Epub 2010 Feb 14.

  55. Kawase-Koga Y, Low R, Otaegi G, Pollock A, Deng H, Eisenhaber F, Maurer-Stroh S, Sun T.
    RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells.
    J Cell Sci. 2010 Feb 15;123(Pt 4):586-94. doi: 10.1242/jcs.059659. Epub 2010 Jan 26.

  56. Sirota FL, Ooi HS, Gattermayer T, Schneider G, Eisenhaber F, Maurer-Stroh S.
    Parameterization of disorder predictors for large-scale applications requiring high specificity by using an extended benchmark dataset.
    BMC Genomics. 2010 Feb 10;11 Suppl 1:S15. doi: 10.1186/1471-2164-11-S1-S15.

  57. Limviphuvadh V, Chua LL, Eisenhaber F, Adhikari S, Maurer-Stroh S.
    Is LGI2 the candidate gene for partial epilepsy with pericentral spikes?
    J Bioinform Comput Biol. 2010 Feb;8(1):117-27.

  58. Schneider G, Wildpaner M, Sirota FL, Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    Integrated tools for biomolecular sequence-based function prediction as exemplified by the ANNOTATOR software environment.
    Methods Mol Biol. 2010;609:257-67. doi: 10.1007/978-1-60327-241-4_15.

  59. Van Durme J, Maurer-Stroh S, Gallardo R, Wilkinson H, Rousseau F, Schymkowitz J.
    Accurate prediction of DnaK-peptide binding via homology modelling and experimental data.
    PLoS Comput Biol. 2009 Aug;5(8):e1000475. doi: 10.1371/journal.pcbi.1000475. Epub 2009 Aug 21.

  60. Ooi HS, Kwo CY, Wildpaner M, Sirota FL, Eisenhaber B, Maurer-Stroh S, Wong WC, Schleiffer A, Eisenhaber F, Schneider G.
    ANNIE: integrated de novo protein sequence annotation.
    Nucleic Acids Res. 2009 Jul;37(Web Server issue):W435-40. doi: 10.1093/nar/gkp254. Epub 2009 Apr 23.

  61. Maurer-Stroh S, Ma J, Lee RT, Sirota FL, Eisenhaber F.
    Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites.
    Biol Direct. 2009 May 20;4:18; discussion 18. doi: 10.1186/1745-6150-4-18.

  62. Reumers J, Maurer-Stroh S, Schymkowitz J, Rousseau F.
    Protein sequences encode safeguards against aggregation.
    Hum Mutat. 2009 Mar;30(3):431-7. doi: 10.1002/humu.20905.

  63. Dhar PK, Thwin CS, Tun K, Tsumoto Y, Maurer-Stroh S, Eisenhaber F, Surana U.
    Synthesizing non-natural parts from natural genomic template.
    J Biol Eng. 2009 Feb 3;3:2. doi: 10.1186/1754-1611-3-2.

  64. Van Damme P, Maurer-Stroh S, Plasman K, Van Durme J, Colaert N, Timmerman E, De Bock PJ, Goethals M, Rousseau F, Schymkowitz J, Vandekerckhove J, Gevaert K.
    Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs.
    Mol Cell Proteomics. 2009 Feb;8(2):258-72. doi: 10.1074/mcp.M800060-MCP200. Epub 2008 Oct 3.

  65. Benetka W, Mehlmer N, Maurer-Stroh S, Sammer M, Koranda M, Neumüller R, Betschinger J, Knoblich JA, Teige M, Eisenhaber F.
    Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling.
    Cell Cycle. 2008 Dec;7(23):3709-19. Epub 2008 Dec 13. Erratum in: Cell Cycle. 2009 Feb 1;8(3):508-9.

  66. Brouwers N, Sleegers K, Engelborghs S, Maurer-Stroh S, Gijselinck I, van der Zee J, Pickut BA, Van den Broeck M, Mattheijssens M, Peeters K, Schymkowitz J, Rousseau F, Martin JJ, Cruts M, De Deyn PP, Van Broeckhoven C.
    Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.
    Neurology. 2008 Aug 26;71(9):656-64. doi: 10.1212/01.wnl.0000319688.89790.7a. Epub 2008 Jun 18.

  67. Sleegers K, Brouwers N, Maurer-Stroh S, van Es MA, Van Damme P, van Vught PW, van der Zee J, Serneels S, De Pooter T, Van den Broeck M, Cruts M, Schymkowitz J, De Jonghe P, Rousseau F, van den Berg LH, Robberecht W, Van Broeckhoven C.
    Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
    Neurology. 2008 Jul 22;71(4):253-9. doi: 10.1212/01.wnl.0000289191.54852.75. Epub 2008 Jan 9.

  68. Sirota FL, Héry-Huynh S, Maurer-Stroh S, Wodak SJ.
    Role of the amino acid sequence in domain swapping of the B1 domain of protein G.
    Proteins. 2008 Jul;72(1):88-104. doi: 10.1002/prot.21901.

  69. Reumers J, Conde L, Medina I, Maurer-Stroh S, Van Durme J, Dopazo J, Rousseau F, Schymkowitz J.
    Joint annotation of coding and non-coding single nucleotide polymorphisms and mutations in the SNPeffect and PupaSuite databases.
    Nucleic Acids Res. 2008 Jan;36(Database issue):D825-9. Epub 2007 Dec 17.

  70. Maurer-Stroh S, Koranda M, Benetka W, Schneider G, Sirota FL, Eisenhaber F.
    Towards complete sets of farnesylated and geranylgeranylated proteins.
    PLoS Comput Biol. 2007 Apr 6;3(4):e66. Epub 2007 Feb 23.

  71. van der Zee J, Le Ber I, Maurer-Stroh S, Engelborghs S, Gijselinck I, Camuzat A, Brouwers N, Vandenberghe R, Sleegers K, Hannequin D, Dermaut B, Schymkowitz J, Campion D, Santens P, Martin JJ, Lacomblez L, De Pooter T, Peeters K, Mattheijssens M, Vercelletto M, Van den Broeck M, Cruts M, De Deyn PP, Rousseau F, Brice A, Van Broeckhoven C.
    Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
    Hum Mutat. 2007 Apr;28(4):416.

  72. Reumers J, Maurer-Stroh S, Schymkowitz J, Rousseau F.
    SNPeffect v2.0: a new step in investigating the molecular phenotypic effects of human non-synonymous SNPs.
    Bioinformatics. 2006 Sep 1;22(17):2183-5. Epub 2006 Jun 29.

  73. Benetka W, Koranda M, Maurer-Stroh S, Pittner F, Eisenhaber F.
    Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo.
    BMC Biochem. 2006 Feb 28;7:6.

  74. Kraft C, Vodermaier HC, Maurer-Stroh S, Eisenhaber F, Peters JM.
    The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.
    Mol Cell. 2005 May 27;18(5):543-53.

  75. Maurer-Stroh S, Eisenhaber F.
    Refinement and prediction of protein prenylation motifs.
    Genome Biol. 2005;6(6):R55. Epub 2005 May 27.

  76. Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T.
    Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes.
    Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10984-9. Epub 2004 Jul 19.

  77. Eisenhaber B, Eisenhaber F, Maurer-Stroh S, Neuberger G.
    Prediction of sequence signals for lipid post-translational modifications: insights from case studies.
    Proteomics. 2004 Jun;4(6):1614-25.

  78. Maurer-Stroh S, Eisenhaber F.
    Myristoylation of viral and bacterial proteins.
    Trends Microbiol. 2004 Apr;12(4):178-85. Review. No abstract available.

  79. Maurer-Stroh S, Gouda M, Novatchkova M, Schleiffer A, Schneider G, Sirota FL, Wildpaner M, Hayashi N, Eisenhaber F.
    MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins.
    Genome Biol. 2004;5(3):R21. Epub 2004 Feb 13.

  80. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM.
    TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.
    Curr Biol. 2003 Sep 2;13(17):1459-68.

  81. Maurer-Stroh S, Washietl S, Eisenhaber F.
    Protein prenyltransferases: anchor size, pseudogenes and parasites.
    Biol Chem. 2003 Jul;384(7):977-89. Review.

  82. Eisenhaber F, Eisenhaber B, Kubina W, Maurer-Stroh S, Neuberger G, Schneider G, Wildpaner M.
    Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1.
    Nucleic Acids Res. 2003 Jul 1;31(13):3631-4.

  83. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence.
    J Mol Biol. 2003 May 2;328(3):581-92.

  84. Neuberger G, Maurer-Stroh S, Eisenhaber B, Hartig A, Eisenhaber F.
    Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences.
    J Mol Biol. 2003 May 2;328(3):567-79.

  85. Eisenhaber B, Maurer-Stroh S, Novatchkova M, Schneider G, Eisenhaber F.
    Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins.
    Bioessays. 2003 Apr;25(4):367-85. Review.

  86. Schleiffer A, Kaitna S, Maurer-Stroh S, Glotzer M, Nasmyth K, Eisenhaber F.
    Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
    Mol Cell. 2003 Mar;11(3):571-5.

  87. Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP.
    The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
    Trends Biochem Sci. 2003 Feb;28(2):69-74.

  88. Maurer-Stroh S, Washietl S, Eisenhaber F.
    Protein prenyltransferases.
    Genome Biol. 2003;4(4):212. Epub 2003 Apr 1. Review.

  89. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence.
    J Mol Biol. 2002 Apr 5;317(4):541-57.

  90. Maurer-Stroh S, Eisenhaber B, Eisenhaber F.
    N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences.
    J Mol Biol. 2002 Apr 5;317(4):523-40.

  91. Flamm C, Hofacker IL, Maurer-Stroh S, Stadler PF, Zehl M.
    Design of multistable RNA molecules.
    RNA. 2001 Feb;7(2):254-65.

 

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