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Dr. Ivana MIHALEK
Principal Investigator
http://epsf.bmad.bii.a-star.edu.sg/
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| Group Members |
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| Name | Title |
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| Dr. MIHALEK Ivana | Principal Investigator |
| Dr. SIKIC Mile | Postdoctoral Fellow |
| Mr. KHOO Aik-Aun, David | Senior Research Officer |
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Research Overview
The aim of our group is to reverse engineer the function of a protein through studying its evolution. We use bioinformatics to get the first inkling of the layout and mechanism of these biological nanomachines, and computer simulation to test, to the extent it currently allows, the reasonableness of our interpretation of bioinformatics data. Ultimately, the goal is to build a straightforward hypothesis which can then be tested experimentally. Therefore we invest serious effort into developing ways to present our findings in the most useful and compact way to our experimentalist colleagues.
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| More Details |
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| Selected Publications |
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- Zong Hong Zhang, Kavitha Bharatham, Sharon M. Q. Chee and Ivana Mihalek.
Cube-DB: detection of functional divergence in human protein families.
Nucl. Acids Res. (2011) doi: 10.1093/nar/gkr1129.
- Bharatham K, Zhang ZH, Mihalek I.
Determinants, Discriminants, Conserved Residues - A Heuristic Approach to Detection of Functional Divergence in Protein Families.
PLoS ONE 6(9): e24382. doi:10.1371/journal.pone.0024382.
- Zong Hong Zhang, Kavitha Bharatham, Westley A. Sherman and Ivana Mihalek.
deconSTRUCT: general purpose protein database search on the substructure level.
Nucleic Acids Research, 2010, doi:10.1093/nar/gkq489.
- Wang H, Chumnarnsilpa S, Loonchanta A, Li Q, Kuan YM, Robine S, Larsson M, Mihalek I, Burtnick LD, Robinson RC.
Helix straightening as an activation mechanism in the gelsolin superfamily of actin regulatory proteins.
J Biol Chem. 2009 Aug 7;284(32):21265-9.
- Ribes-Zamora A, Mihalek I, Lichtarge O, Bertuch AA.
Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions.
Nat Struct Mol Biol. 2007 Apr;14(4):301-7.
- Mihalek I, Res I, Lichtarge O.
A family of evolution-entropy hybrid methods for ranking protein residues by importance.
J Mol Biol. 2004 Mar 5;336(5):1265-82.
- Mihalek I, Res I, Yao H, Lichtarge O.
Combining inference from evolution and geometric probability in protein structure evaluation.
J Mol Biol. 2003 Aug 1;331(1):263-79.
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