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Dr. Mallur Srivatsan MADHUSUDHAN
Principal Investigator
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| Group Members |
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| Name | Title |
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| Dr. MADHUSUDHAN Mallur Srivatsan | Principal Investigator |
| Dr. NGUYEN Ngoc Minh | Postdoctoral Fellow |
| Mr. LI Kun Quan | Research Officer |
| Mr. TAN Kuan Pern | Research Officer |
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Research Overview
Our aim is to accurately model the 3D structures of proteins and their complexes. To this end, we combine the laws of physics along with experimental observation and statistics to develop computational methods in structural biology. The methods are tested, often in close collaboration with experimental biologists, on particular systems of interest. Our research gives detailed information of cellular processes and hence impacts research on human health, nutrition and biology as a whole.
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| More Details |
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| Selected Publications |
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- Nguyen MN, Tan KP, Madhusudhan MS.
CLICK--topology-independent comparison of biomolecular 3D structures.
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W24-8. Epub 2011 May 20.
PMID: 21602266 [PubMed - in process]
- Nguyen MN, Madhusudhan MS.
Biological insights from topology independent comparison of protein 3D structures.
Nucleic Acids Res. 2011 Aug;39(14):e94. Epub 2011 May 19.
PMID: 21596786 [PubMed - in process]
- Tan KP, Varadarajan R, Madhusudhan MS.
DEPTH: a web server to compute depth and predict small-molecule binding cavities in proteins.
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W242-8. Epub 2011 May 16.
PMID: 21576233 [PubMed - in process]
- Knehans T, Schüller A, Doan DN, Nacro K, Hill J, Güntert P, Madhusudhan MS, Weil T, Vasudevan SG.
Structure-guided fragment-based in silico drug design of dengue protease inhibitors.
J Comput Aided Mol Des. 2011 Mar;25(3):263-74. Epub 2011 Feb 23.
PMID: 21344277 [PubMed - indexed for MEDLINE]
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