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Dr. Henry YANG
Principal Investigator
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| Group Members |
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| Name | Title |
| Dr. LEE Kian Leong |
Postdoctoral Fellow |
| Mr. JIANG Changde, Donald |
Research Associate |
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Research Overview
The group's main research activities have been focused on analysis and integration of genomic data to perform data-driven discovery using an integrated and interdisciplinary approach (Bioinformatics, Systems Biology, & Stem Cell Biology). Bioinformatics (computational and comparative genomics) serves to provide computational tools for mining of large-scale data and integrated annotation, while Systems Biology approaches are employed for the integration of different bioassay platforms (MPSS/SAGE, cDNA microarray, ChIP/chip array, & CGH array) and statistical pathway analysis. Both Bioinformatics and Systems Biology approaches are linked with Biology for novel gene/pathway identification and experimental validation. Thus most research projects are collaborative with Stem Cell biologists from GIS. The group also works with wetlab biologists in other research areas such as cancer, dry eye and immunology.
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| More Details |
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| Selected Publications |
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- Tay YM, Tam WL, Ang YS, Gaughwin PM, Yang H, Wang W, Liu R, George J, Ng HH, Perera RJ, Lufkin T, Rigoutsos I, Thomson AM, Lim B.
MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1.
Stem Cells. 2008 Jan;26(1):17-29. Epub 2007 Oct 4.
PMID: 17916804 [PubMed - in process]
- Soh BS, Song CM, Vallier L, Li P, Choong C, Yeo BH, Lim EH, Pedersen RA, Yang HH, Rao M, Lim B.
Pleiotrophin enhances clonal growth and long-term expansion of human embryonic stem cells.
Stem Cells. 2007 Dec;25(12):3029-37. Epub 2007 Sep 6.
PMID: 17823238 [PubMed - in process]
- Choong ML, Yang HH, McNiece I.
MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis.
Exp Hematol. 2007 Apr;35(4):551-64.
PMID: 17379065 [PubMed - indexed for MEDLINE]
- Chua SW, Vijayakumar P, Nissom PM, Yam CY, Wong VV, Yang H.
A novel normalization method for effective removal of systematic variation in microarray data.
Nucleic Acids Res. 2006 Mar 9;34(5):e38. Print 2006.
PMID: 16528099 [PubMed - indexed for MEDLINE]
- Chen L, Sze SK, Yang H.
Automated intensity descent algorithm for interpretation of complex high-resolution mass spectra.
Anal Chem. 2006 Jul 15;78(14):5006-18.
PMID: 16841924 [PubMed - indexed for MEDLINE]
- Yang H.
On the search of better validation and statistical mthods in microarray data analysis. In "Information Processing and Living Systems" (Ed. Bajic VB, Tan TW)
Imperial College Press. 2005: 729-740
- Mathavan S, Lee SG, Mak A, Miller LD, Murthy KR, Govindarajan KR, Tong Y, Wu YL, Lam SH, Yang H, Ruan Y, Korzh V, Gong Z, Liu ET, Lufkin T.
Transcriptome analysis of zebrafish embryogenesis using microarrays.
PLoS Genet. 2005 Aug;1(2):260-76. Epub 2005 Aug 26.
PMID: 16132083 [PubMed]
- Yang H, Allen DG.
Potential Improvement in Biofilter Design Through the Use of Heterogeneous Packing and Conical Biofilter Geometry.
J. Environ. Eng. 2005 Apr;131(4):504-511
- Lo TL, Yusoff P, Fong CW, Guo K, McCaw BJ, Phillips WA, Yang H, Wong ES, Leong HF, Zeng Q, Putti TC, Guy GR.
The ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer.
Cancer Res. 2004 Sep 1;64(17):6127-36.
PMID: 15342396 [PubMed - indexed for MEDLINE]
- Yang H, Haddad H, Tomas C, Alsaker K, Papoutsakis ET.
A segmental nearest neighbor normalization and gene identification method gives superior results for DNA-array analysis.
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1122-7. Epub 2003 Jan 15.
PMID: 12529501 [PubMed - indexed for MEDLINE]
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