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BII's unique combination of research groups from different disciplines (gene expression, protein sequence, protein structure, bioimaging) opens the opportunity to cover a wide range of aspects of collaborative research on infectious diseases that are not easily found under the same roof in other institutes. To coordinate our efforts, we have established a cross-division research programme on human infectious diseases.
 
Known for being at the forefront of research during the 2009 (H1N1) pandemic, we are well prepared for coming influenza seasons, new pandemics and challenges of novel infectious agents. We are also involved in the development of new antibiotics to treat eye infections and participate in several other local and international efforts on infectious diseases. Interested clinicians, industry partners, researchers and health authorities are welcome to contact the programme director (Sebastian Maurer-Stroh) for collaborations.
 
Current main research areas:
  • Influenza
  • Flaviviruses (Dengue and Zika)
    • Structure-guided in silico drug design of dengue protease inhibitors.
      (in collaboration with Duke-NUS, ETC, Goethe University Frankfurt and University of Ulm)

  • Antibacterial drugs
    • Defensin derived antimicrobials with a focus on eye infections
      (in collaboration with Singapore Eye Research Institute (rwbeuer@mac.com), NTU, NUS, Singapore General Hospital Pathology)
      • new molecules in pre-clinical testing show activity against clinical strains of Pseudomonas, MRSA and fungus
      • Visit Defensins Knowledgebase
    • Computational antibiotic susceptibility profiles from whole genome data
    • Automated classification of beta-lactamases based on substrate binding pocket similarities
      (in collaboration with SGH and NPHL/MOH)

  • Contributions to A*STAR BMRC infectious disease research topics:
    • Influenza vaccine
    • Tuberculosis
    • Malaria
    • Dengue
    • HFMD/EV71
 
Recent publications:

Virk RK, Gunalan V, Lee HK, Inoue M, Chua C, Tan BH, Tambyah PA. Molecular Evidence of Transmission of Influenza A/H1N1 2009 on a University Campus. PLoS One. 2017 Jan 6;12(1):e0168596. doi: 10.1371/journal.pone.0168596. PubMed PMID: 28060851.

Su CT, Ling WL, Lua WH, Haw YX, Gan SKE. Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance. BMC Bioinformatics. 2016 Dec 17(19):219-228. doi: 10.1186/s12859-016-1372-3

Samsudin F, Ortiz-Suarez ML, Piggot TJ, Bond PJ, Khalid S. OmpA: A Flexible Clamp for Bacterial Cell Wall Attachment. Structure. 2016 Dec 6;24(12):2227-2235. doi: 10.1016/j.str.2016.10.009. PubMed PMID: 27866852.

Lipsitch M, Barclay W, Raman R, Russell CJ, Belser JA, Cobey S, Kasson PM, Lloyd-Smith JO, Maurer-Stroh S, Riley S, Beauchemin CA, Bedford T, Friedrich TC, Handel A, Herfst S, Murcia PR, Roche B, Wilke CO, Russell CA. Viral factors in influenza pandemic risk assessment. Elife. 2016 Nov 11;5. pii: e18491. doi: 10.7554/eLife.18491. PubMed PMID: 27834632; PubMed Central PMCID: PMC5156527.

Raj P, Tay J, Ang LW, Tien WS, Thu M, Lee P, Pang QY, Tang YL, Lee KY, Maurer-Stroh S, Gunalan V, Cutter J, Goh KT. A large common-source outbreak of norovirus gastroenteritis in a hotel in Singapore, 2012. Epidemiol Infect. 2017 Feb;145(3):535-544. doi: 10.1017/S095026881600248X. PubMed PMID: 27788694.

Huber RG, Marzinek JK, Holdbrook DA, Bond PJ. Multiscale molecular dynamics simulation approaches to the structure and dynamics of viruses. Prog Biophys Mol Biol. 2016 Oct 17. pii: S0079-6107(16)30081-5. doi: 10.1016/j.pbiomolbio.2016.09.010. [Epub ahead of print] Review. PubMed PMID: 27765545.

Maurer-Stroh S, Mak TM, Ng YK, Phuah SP, Huber RG, Marzinek JK, Holdbrook DA, Lee RT, Cui L, Lin RT. South-east Asian Zika virus strain linked to cluster of cases in Singapore, August 2016. Euro Surveill. 2016 Sep 22;21(38). doi: 10.2807/1560-7917.ES.2016.21.38.30347. PubMed PMID: 27684526; PubMed Central PMCID: PMC5073200.

Mendenhall IH, Borthwick S, Neves ES, Low D, Linster M, Liang B, Skiles M, Jayakumar J, Han H, Gunalan V, Lee BP, Okahara K, Wang LF, Maurer-Stroh S, Su YC, Smith GJ. Identification of a Lineage D Betacoronavirus in Cave Nectar Bats (Eonycteris spelaea) in Singapore and an Overview of Lineage D Reservoir Ecology in SE Asian Bats. Transbound Emerg Dis. 2016 Sep 16. doi: 10.1111/tbed.12568. [Epub ahead of print] PubMed PMID: 27637887.

Krawczyk K, Sim AY, Knapp B, Deane CM, Minary P. Tertiary Element Interaction in HIV-1 TAR. J Chem Inf Model. 2016 Sep 26;56(9):1746-54. doi: 10.1021/acs.jcim.6b00152. PubMed PMID: 27500460.

Chen H, Deng Q, Ng SH, Lee RT, Maurer-Stroh S, Zhai W. Dynamic Convergent Evolution Drives the Passage Adaptation across 48 Years' History of H3N2 Influenza Evolution. Mol Biol Evol. 2016 Dec;33(12):3133-3143. PubMed PMID: 27604224.

Hurt AC, Besselaar TG, Daniels RS, Ermetal B, Fry A, Gubareva L, Huang W, Lackenby A, Lee RT, Lo J, Maurer-Stroh S, Nguyen HT, Pereyaslov D, Rebelo-de-Andrade H, Siqueira MM, Takashita E, Tashiro M, Tilmanis D, Wang D, Zhang W, Meijer A. Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015. Antiviral Res. 2016 Aug;132:178-85. doi: 10.1016/j.antiviral.2016.06.001. PubMed PMID: 27265623.

Marzinek JK, Holdbrook DA, Huber RG, Verma C, Bond PJ. Pushing the Envelope: Dengue Viral Membrane Coaxed into Shape by Molecular Simulations. Structure. 2016 Aug 2;24(8):1410-20. doi: 10.1016/j.str.2016.05.014. PubMed PMID: 27396828.

Morkunas B, Gal B, Galloway WR, Hodgkinson JT, Ibbeson BM, Tan YS, Welch M, Spring DR. Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells. Beilstein J Org Chem. 2016 Jul 11;12:1428-33. doi: 10.3762/bjoc.12.137. PubMed PMID: 27559393; PubMed Central PMCID: PMC4979876.

Kamran M, Sinha S, Dubey P, Lynn AM, Dhar SK. Identification of putative Z-ring-associated proteins, involved in cell division in human pathogenic bacteria Helicobacter pylori. FEBS Lett. 2016 Jul;590(14):2158-71. doi: 10.1002/1873-3468.12230. PubMed PMID: 27253179.

Garg H, Lee RT, Maurer-Stroh S, Joshi A. HIV-1 adaptation to low levels of CCR5 results in V3 and V2 loop changes that increase envelope pathogenicity, CCR5 affinity and decrease susceptibility to Maraviroc. Virology. 2016 Jun;493:86-99. doi: 10.1016/j.virol.2016.03.010. PubMed PMID: 27017055.

Hapuarachchi HC, Koo C, Kek R, Xu H, Lai YL, Liu L, Kok SY, Shi Y, Chuen RL, Lee KS, Maurer-Stroh S, Ng LC. Intra-epidemic evolutionary dynamics of a Dengue virus type 1 population reveal mutant spectra that correlate with disease transmission. Sci Rep. 2016 Mar 4;6:22592. doi: 10.1038/srep22592. PubMed PMID: 26940650; PubMed Central PMCID: PMC4778070.

Virk RK, Gunalan V, Tambyah PA. Influenza infection in human host: challenges in making a better influenza vaccine. Expert Rev Anti Infect Ther. 2016;14(4):365-75. doi: 10.1586/14787210.2016.1155450. Review. PubMed PMID: 26885890.

Wee KB, Lee RT, Lin J, Pramono ZA, Maurer-Stroh S. Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance. PLoS Comput Biol. 2016 Jan 15;12(1):e1004663. doi: 10.1371/journal.pcbi.1004663. PubMed PMID: 26771381; PubMed Central PMCID: PMC4714944.

Maurer-Stroh S, Lee CW, Patel C, Lucero M, Nohynek H, Sung WK, Murad C, Ma J, Hibberd ML, Wong CW, Simões EA. Comparison of microarray-predicted closest genomes to sequencing for poliovirus vaccine strain similarity and influenza A phylogeny. Diagn Microbiol Infect Dis. 2016 Mar;84(3):203-6. doi: 10.1016/j.diagmicrobio.2015.11.003. PubMed PMID: 26658310.

Van TD, Tran N, Le L, Eisenhaber F. A Perspective on Rational Designs of a Hemagglutinin Based Universal Influenza Vaccine. Curr Pharm Des. 2016 Apr 19. [Epub ahead of print] PubMed PMID: 24308491.

Marzinek JK, Lakshminarayanan R, Goh E, Huber RG, Panzade S, Verma C, Bond PJ. Characterizing the Conformational Landscape of Flavivirus Fusion Peptides via Simulation and Experiment. Sci Rep. 2016 Jan 20;6:19160. doi: 10.1038/srep19160. PubMed PMID: 26785994; PubMed Central PMCID: PMC4726195.

Cording A, Gormally M, Bond PJ, Carrington M, Balasubramanian S, Miska EA, Thomas B. Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications. RNA Biol. 2016 Jan 20:1-9. [Epub ahead of print] PubMed PMID: 26786754.
 
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