Antibody and Product Development
Dr. GAN Ken En Samuel
Principal Investigator

Group Members
Dr. GAN SamuelPrincipal Investigator
Dr. SU Tran To ChinhPostdoctoral Fellow
Mr. LUA Wai HengResearch Manager
Mr. CHAN Kwok FongResearch Officer
Mr. LING Wei LiResearch Officer
Ms. WU WeilingSoftware Technician
Mr. POH Jun JieLaboratory Officer

Research Overview

This newly formed team was officially set up from the Biomolecular Modeling and Design Division in Oct 2013 to be part of the new Translational Research division to work on three streams: therapeutic antibodies; drug design; and product development. Working closely with other groups in BII and both within and beyond A*STAR, the interdisciplinary nature of streams spans across molecular cell biology, computational science, complexity sciences, and biomolecular modeling.

More Details

Publications/Inventions by discipline


  1. Phua SX, Gan SKE (2018).
    A paradigm shift in the view of proteins: impact on the computational analysis of allostery, antibody engineering and drug discovery.
    In Review.
  2. Su CTT, Lua WH, Ling WL, Gan SKE (2018).
    Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen Binding.
    In Review. Preprint available.
  3. Phua SX, Lua WH, Gan SKE (2018).
    Role of FcαR EC2 region in extracellular membrane localization.
    Cell Cycle. 5 April 2018; doi: 10.1080/15384101.2018.1444236.
  4. Ling WL, Lua WH, Poh JJ, Yeo JY, Lane DP, Gan SKE (2018).
    Effect of VH-VL families in Pertuzumab and Trastuzumab recombinant production, Her2 and FcgIIA-binding.
    Frontiers in Immunology. Mar 12, 2018, 9:469 doi: 10.3389/fimmu.2018.00469.
  5. Chiang RZH, Gan SKE, Su CTT (2018).
    A computational study for rational HIV-1 non-nucleoside Reverse Transcriptase inhibitor selection and the discovery of novel allosteric pockets for inhibitor design.
    Bioscience Reports. 05 March 2018, 38 (2) doi:10.1042/BSR20171113 Doi: 10.1042/BSR20171113.
  6. Lua WH, Ling WL, Yeo JY, Poh JJ, Lane DP, Gan SKE (2018).
    The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding.
    Scientific Reports, 15 January 2018. 8:718 doi: 10.1038/s41598-017-18892-9.
  7. Su CTTC, Kwoh CK, Verma CS, Gan SKE (2017).
    Modeling the full length HIV-1 Gag polyprotein reveals the role of its p6 subunit in viral maturation and the effect of non-cleavage site mutations in protease drug resistance.
    Journal of Biomolecular Structure & Dynamics. 27 December 2017: 1-12. Doi: 10.1080/07391102.2017.1417160.
  8. Su CTTC, Ling WL, Lua WH, Poh JJ, Gan SKE (2017).
    The role of Antibody Vκ Framework 3 region towards Antigen binding: serendipitous effects on recombinant production and Protein L binding.
    Scientific Reports, 19 June 2017 7: 3766 doi: 10.1038/s41598-017-02756-3.
  9. Lua WH, Ling WL, Su CTT, Yeo JY, Verma CS, Eisenhaber B, Eisenhaber F, Gan SKE (2017).
    Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: a story of bad signal peptides and good ones that nevertheless do not make it.
    5 February 2017. 16:5, 457-467 Doi:10.1080/15384101.2017.1281480.
  10. Su CTT, Ling WL, Lua WH, Haw YX, Gan SKE (2016).
    Structural analyses of 2015-updated drug-resistant mutations in HIV-1 Protease: An implication of Protease Inhibitor cross-resistance.
    BMC Bioinformatics. 17(Suppl 19):500. 22 December 2016 doi: 10.1186/s12859-016-1372-3.
  11. Lua WH, Gan SKE, Lane DP, Verma CS (2015).
    A search for synergy in the binding kinetics of Trastuzumab and Pertuzumab whole and F(ab) to Her2.
    NPJ Breast Cancer. 1, 15012. 5 August 2015. Doi: 10.1038/npjbcancer.2015.12.
  12. Ling WL, Lua WH, Gan SKE (2015).
    Fast Reversible Single-Step Method for Enhanced Band Contrast of Polyacrylamide Gels for Automated Detection.
    Electrophoresis. 17 March 2015, 0, 1–4.. doi: 10.1002/elps.201500094.
  13. Jiang Y,Tan CY,Tan SY, Wong MSF, Chen YF, Zhang L, Yao K, Gan SKE, Verma CS, Tan YJ (2014).
    SAW Sensor for Influenza A Virus Detection Enabled with Efficient Surface Functionalization.
    Sensors and Actuators B: Chemical, 209, 78–84 24 November 2014. doi:10.1016/j.snb.2014.11.103.
  14. Gan SKE.
    Rapid Humanization and Rodentization of Monoclonal Antibodies.
    Invention filed Aug 2013 BII/Z/07997.
  15. Gan SKE.
    Novel BSL2 platform for RNA-virus drug escape mutation and prediction.
    Invention filed May 2013: BII/Z/07970.
  16. Oh HLJ, Gan SKE, Bertoletti A, Tan YJ (2012).
    Understanding the T cell immune response in SARS coronavirus infection. Emerging Microbes & Infections NPG.
    5 September 2012, 1, e23; DOI: 10.1038/emi.2012.26.
  17. Karagiannis P, Singer J, Hunt J, Gan SKE, Rudman SM, Mechtcheriakova D, Knittelfelder R, Daniels TR, Hobson PS, Beavil AJ, Spicer S, Nestle F, Penichet ML, Gould HJ, Jensen-Jarolim E, Karagiannis SN.
    Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/ neu -positive tumour cells.
    Cancer Immunology, Immunotherapy, 22 October 2008. June 2009, Volume 58, Issue 6, pp 915–930.
  18. Gan SKE, Hunt J, Marsh PJ, Beavil, AJ, Harries, HE.
    Method (Recombinant human Ig production).
    International Publication Number WO 2009/150426 A2. 17 Dec 2009.
  19. Gan SKE, Loh CY, Seet HY.
    Hypertension in Young Adults – An Under-Estimated Problem.
    in Singapore Medical Journal (SMJ) 2003; 44(9):448-52 – feature article of Sept 2003 issue.
  20. Tan JE, Wong SC, Gan SKE, Xu S, Lam KP.
    The Adaptor Protein BLNK Is Required for B Cell Antigen Receptor-induced Activation of Nuclear Factor-κβ and Cell Cycle Entry and Survival of B Lymphocytes.
    Journal of Biological Chemistry (JBC) 23 March 2001; 276 (23).
    Issue of June 8, pp 20055-20063.


  1. Gan SKE (2018).
    Editorial: A New Home for "Scientific Phone Apps and Mobile Devices" Journal.
    Scientific Phone Apps and Mobile Devices. 26 April 2018, 4: 3. doi: 10.30943/2018/26042018.
  2. Gan SKE (2018).
    Editorial: The history and future of Scientific Phone Apps and Mobile Devices.
    Scientific Phone Apps and Mobile Devices. 19 March 2018, 4: 2. doi: 10.1186/s41070-018-0022-8.
  3. Gan SKE (2018).
    Editorial: APD Trove Journal – scope, aims, and purpose.
    APD Trove 2018, 1 March 2018, 1:1. doi: 10.30943/2018/312018
  4. Budiano IH, Gan SKE (2017).
    APD Volumetric App: Android App for the quantification of reagents.
    Scientific Phone Apps and Mobile Devices 3 November 2017, 3:7, doi:10.1186/s41070-017-0019-8.
  5. Sim JZ, Nguyen PV, Zang Y, Leow MKS. Gan SKE (2017).
    Thyroid-SPOT: Thyroid treatment management app.
    Scientific Phone Apps. 30 August 2017, 3: 4, doi: 10.1186/s41070-017-0016-y.
  6. Sim JZ, Nguyen PV, Gan SKE, Leow MKS.
    Thyroid-SPOT for Android and iOS.
    - Invention filed May 2015 SICS/Z/09136.
  7. Ng KM, Wong CF, Liang AX, Liew YH, Yeo JY, Lua WH, Qian XJ, Gan SKE (2017).
    APD SpectBT: Arduino-based mobile vis-Spectrophotometer.
    Nature Methods Application Notes. March 14 2017 doi:10.1038/an9827.
  8. Wong CF, Yeo JY, Gan SKE (2016).
    APD Colony Counter App: Using Watershed Algorithm for improved colony counting.
    Nature Methods Application Notes. 9 Aug 2016 doi:10.1038/ an9774.
  9. Gan SKE, Koshy C, Nguyen PV, Haw YX (2016).
    An Overview of clinically and healthcare related apps in Google and Apple app stores: connecting patients, drugs, and clinicians.
    Scientific Phone Apps and Mobile Devices. 19 July 2016, 2:8. doi: 10.1186/s41070-016-0012-7.
  10. Gan SKE, Poon JK (2016).
    The World of Biomedical Apps: their uses, limitations, and potential.
    Scientific Phone Apps and Mobile Devices. 19 July 2016, 2:6. doi: 10.1186/s41070-016-0009-2.
  11. Nguyen PV, Ghezal A, Hsueh YC, Boudier T, Gan SKE, Lee HK (2016).
    Optimal processing for gel electrophoresis images: Applying Monte Carlo Tree Search in GelApp.
    Electrophoresis. 2 June 2016, 37, 2208–2216, doi: 1.1002/elps.201600197.
  12. Ng KM, Nguyen PV, Sukiman IF, Gan SKE (2016).
    VibraTilt: Accelerometer & Gyroscope measurement app. Scientific Phone Apps and Mobile Devices.
    18 April 2016,2:5. doi: 10.1186/s41070-016-0008-3.
  13. Sim JZ, Nguyen PV, Zang Y, Gan SKE (2016).
    DNA2App: Mobile sequence analyzer.
    Scientific Phone Apps and Mobile Devices. 2 April 2016, 2:2. doi: 10.1186/s41070-016-0004-7.
  14. Gan SKE, Goh BYL (2016).
    Editorial: A dearth of apps for psychology: the mind, the phone, and the battery.
    Scientific Phone Apps and Mobile Devices. 2 April 2016, 2:1. doi: 10.1186s41070-016-0005-6.
  15. Nguyen PV, Lim JPH, Budianto IH, Gan SKE (2015).
    PsychVey: Research Survey App.
    Scientific Phone Apps and Mobile Devices, 13 October 2015,1:3, doi:10.1186/s41070-015-0002-1.
  16. Budianto IH, Wong CF, Nguyen PV, Gan SKE (2015).
    StanXY: Standard Curve App for Android.
    Scientific Phone Apps and Mobile Devices. 15 December 2015, 1:2. doi:10.1186/s41070-015-0003-0.
  17. Gan SKE (2015).
    Editorial: scientific Apps: design, considerations, and functions.
    Scientific Phone Apps and Mobile Devices. 14 December 2015, 1:1. doi:10.1186/s41070-015-0001-2.
  18. Gan SKE (2015).
    With GelApp, Say Goodbye to Band Size Estimations!
    AES Newsletter. Aug 2015, 20, 2.
  19. Sim JZ, Nguyen PV, Gan SKE, Leow MKS.
    Thyroid-SPOT for Android and iOS.
    - Invention filed May 2015 SICS/Z/09136.
  20. Sim, JZ., Nguyen, PV., Lee, HK., Gan, SKE (2015).
    GelApp: Mobile gel electrophoresis analyzer.
    Nature Methods Application Notes. 14 April 2015. doi:10.1038/an9643.
  21. Sim JZ, Nguyen PV, Lim JPH, Su TTC, Gan SKE (2015).
    The Rise of the Mobile Lab: the Use of Smartphone Apps for Biomedical Research.
    Asia Pacific Biotech News, 2015,19:58 doi: 10.1142/S021903031500021X.
  22. Gan SKE (2015).
    Use of SmartPhone Apps for Biomedical Research.
    Biospectrum. 7 March 2015.
  23. Poh JJ, Gan SKE (2014).
    Comparison of Customized Spin-Column and Salt-Precipitation Finger-Prick Blood DNA Extraction.
    Bioscience Reports. 1 October 2014, 34, art:e00145 doi:10.1042/BSR20140105.
  24. Nguyen PV, Verma CS, Gan SKE (2014).
    DNAApp: a mobile application for sequencing data analysis.
    Bioinformatics. 5 August 2014 ;30(22):3270-1 doi:10.1093/bioinformatics/btu525. Tech disclosure filed Mar 2014: BII/Z/08384; Covered in over 80 news agencies worldwide, including Nasdaq, Yahoo Finance, Bloomberg, Life Scientist, etc; 1st in Top 10 apps for busy researchers (Biotechniques 2014).
  25. Poh JJ, Gan SKE (2014).
    The Determination of Factors involved in Column-Based Nucleic Acid Extraction and Purification.
    Journal of Bioprocessing and Biotechniques. 12 June 2014; 4:157. doi: 10.4172/2155-9821.1000157.
    -Products commercialized by Quintech Life Sciences Pte Ltd, carried by BSF, A*STAR.
  26. Chan, W.T., Verma, C.S., Lane, D.P. and Gan, S.K. (2013).
    A comparison and optimization of methods and factors affecting the Transformation of Escherichia coli.
    Biosci. Rep. 1 December 2013; 33(6), art:e00086.doi:10.1042/BSR20130098.
  27. Gan SKE.
    Optimization of QIAGEN and OEM miniprep and Gel/PCR extraction kits.
    – Tech disclosure filed Oct 2013: BII/Z/08123.

Psychology/Social Sciences

  1. Ng RYX, Wong YS, Yeo JY, Koh CLZ, Gan SKE (2018).
    The Associations between Dietary Practices and Dietary Quality, Biological Health Indicators, Perceived Stress, Religiosity, Culture, and Gender in Multi-Cultural Singapore.
    In Review.
  2. Gan SKE, Goh BYL, Yeo JYY (2018).
    Psycho-otorhinomicrobiology: The link between the flora of the nose and ears and that of the psyche.
    In Review.
  3. Chew ASQ, Yu YT, Chua SW, Gan SKE (2016).
    The effects of familiarity and language of background music on working memory and language tasks in Singapore.
    Psychology of Music. 21 March 2016; Vol 44 (6): 1431–1438. doi: 10.1177/0305735616636209.
  4. Gan SKE., Lim MJ (2015).
    Chapter 2: Awareness of Others. Chapter contribution to James Cook, Singapore book publication "First Class Behaviours for a First World Nation - SG50 Edition."
    E-Published 16 Dec 2015. James Cook University. Pg 23-39, ISBN: 978-981-09-8281-2.
  5. Gan SKE, Lim MJ, Haw YX (2015).
    The Relaxation Effects of Stimulative and Sedative Music on Mathematics Anxiety: A Perception to Physiology Model.
    Psychology of Music. 19 June 2015; 44(4): 730–741. doi:10.1177/0305735615590430.
  6. Yew SH, Lim KMJ, Haw YX, Gan SKE (2015).
    The Interaction between Perceived Stress, Optimisim, Life Satisfaction and Physical Health in the Singaporean Asian Context.
    Asian Journal of Humanities and Social Sciences. 1 Feb 2015; 3 (1). pp. 1-11.
  7. SKE Gan.
    Psychoneuroimmunology – Not a mouthful but a hidden and controversial field
    Featured article in Open University Psychological Society Newsletter – August 2009.


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