Chemical Genomics
Dr. ARUMUGAM Prakash
Principal Investigator

Group Members
Dr. ARUMUGAM PrakashPrincipal Investigator
Dr. Mohammad AlfatahPostdoctoral Fellow
Ms. WONG Jin HueiResearch Officer
Ms. GOH Jie Hui, CorinnaResearch Officer

Research Overview

We employ the Forward/Reverse Chemical Genetic tools in the unicellular yeast Saccharomyces cerevisiae (budding yeast) to uncover mechanism of action of bioactive compounds, screen for inhibitors of Protein-Protein Interaction and reveal functions of conserved signaling complexes.

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Selected Publications
  1. Siew Bee Ng, Yoganathan Kanagasundaram, Hao Fan, Prakash Arumugam, Birgit Eisenhaber & Frank Eisenhaber.
    The 160K Natural Organism Library, a unique resource for natural products research.
    Nature Biotechnology, Vol. 36, No. 7, July 2018, Pg 570-573, doi: 10.1038/nbt.4187.

  2. Ng SMS, Yap JM, Lau QY, Ng FM, Ong EHQ, Barkham T, Teo JWP, Alfatah M, Kong KW, Hoon S, Arumugam P, Hill J, Chia CSB.
    Structure-activity relationship studies of ultra-short peptides with potent activities against fluconazole-resistant Candida albicans.
    Eur J Med Chem. 2018 Mar 9;150:479-490. doi: 10.1016/j.ejmech.2018.03.027.

  3. Wong JH, Alfatah M, Sin MF, Sim HM, Verma CS, Lane DP, Arumugam,P.
    A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53.
    BMC Biology 2017 15:108.

  4. Kerr GW, Wong JH and Arumugam P.
    PP2ACdc55's role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function.
    Scientific Reports 6, (2016) doi:10.1038/srep30397.

  5. Sarkar S, Dalgaard JZ, Millar JB, Arumugam P.
    The Rim15-endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast.
    PLoS Genet. 2014 Jun 26;10(6):e1004456.

  6. Copsey, A., Tang, S., Jordan, P.W., Blitzblau, H., Newcombe, S., Chi-ho Chan, A., Newnham, L., Li, Z., Arumugam, P., Hochwagen, A., Hunter, N., Hoffmann, E.
    The SMC5/6 complex ensures chromosome segregation by promoting resolution of meiotic recombination intermediates and regulating the stepwise loss of meiotic cohesion.
    PLoS Genet. 2013;9(12):e1004071.

  7. Tibbles, K. L., Sarkar, S., Novak, B., Arumugam, P.
    CDK-dependent nuclear localization of B-cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast.
    (2013) PLoS One 8(11): e79001.

  8. Sarkar, S., Shenoy, R.T., Dalgaard, J.Z., Newnham, L., Hoffmann, E., Millar, J. B. A., Arumugam, P.
    Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores during meiosis I.
    (2013) PLoS Genet 9(7): e1003610.

  9. Koulintchenko, M., Vengrova, S., Eydmann, T., Arumugam, P., and Dalgaard, J.Z.
    DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.
    (2012) PloS One 7(10): e47091.

  10. Kerr, G.W., Sarkar, S., and Arumugam, P.
    How to halve ploidy: lessons from budding yeast meiosis.
    Cell Mol Life Sci. 2012 Apr 6.

  11. Kerr, G.W., Sarkar, S., Tibbles, K.L., Petronczki, M., Millar, J.B.A., Arumugam, P.
    Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk.
    (2011) The Journal of Cell Biology 193(7):1157-66.

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