Chemical Genomics
Dr. ARUMUGAM Prakash
Principal Investigator

Group Members
Dr. ARUMUGAM PrakashPrincipal Investigator
Dr. Mohammad AlfatahPostdoctoral Fellow
Ms. WONG Jin HueiResearch Officer
Research Overview

We exploit the experimental tractability of unicellular yeast Saccharomyces cerevisiae (budding yeast) to contribute to molecular bioinformatics. Our primary goal is to apply chemical profiling methods in yeast, to determine targets of naturally occurring compounds, reveal functions of unannotated genes and deconstruct complex regulatory networks required for cellular growth and proliferation. In addition, we will identify principles of substrate recognition by PP2A protein phosphatases in vivo in order to establish novel algorithms to predict substrates of PP2A.
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Selected Publications
  1. Kerr GW, Wong JH and Arumugam P.
    PP2ACdc55's role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function.
    Scientific Reports 6, (2016) doi:10.1038/srep30397.

  2. Sarkar S, Dalgaard JZ, Millar JB, Arumugam P.
    The Rim15-endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast.
    PLoS Genet. 2014 Jun 26;10(6):e1004456.

  3. Copsey, A., Tang, S., Jordan, P.W., Blitzblau, H., Newcombe, S., Chi-ho Chan, A., Newnham, L., Li, Z., Arumugam, P., Hochwagen, A., Hunter, N., Hoffmann, E.
    The SMC5/6 complex ensures chromosome segregation by promoting resolution of meiotic recombination intermediates and regulating the stepwise loss of meiotic cohesion.
    PLoS Genet. 2013;9(12):e1004071.

  4. Tibbles, K. L., Sarkar, S., Novak, B., Arumugam, P.
    CDK-dependent nuclear localization of B-cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast.
    (2013) PLoS One 8(11): e79001.

  5. Sarkar, S., Shenoy, R.T., Dalgaard, J.Z., Newnham, L., Hoffmann, E., Millar, J. B. A., Arumugam, P.
    Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores during meiosis I.
    (2013) PLoS Genet 9(7): e1003610.

  6. Koulintchenko, M., Vengrova, S., Eydmann, T., Arumugam, P., and Dalgaard, J.Z.
    DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.
    (2012) PloS One 7(10): e47091.

  7. Kerr, G.W., Sarkar, S., and Arumugam, P.
    How to halve ploidy: lessons from budding yeast meiosis.
    Cell Mol Life Sci. 2012 Apr 6.

  8. Kerr, G.W., Sarkar, S., Tibbles, K.L., Petronczki, M., Millar, J.B.A., Arumugam, P.
    Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk.
    (2011) The Journal of Cell Biology 193(7):1157-66.

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