Natural Product Chemistry
Principal Investigator

Group Members
Dr. KANAGASUNDARAM YoganathanPrincipal Investigator
Dr. CHING Kuan ChiehPostdoctoral Fellow
Dr. NGE Choy EngPostdoctoral Fellow
Ms. YANG Lay KienResearch Officer
Research Overview

The primary focus of my group is to explore the chemical diversity of A*STAR Natural Product Library (A*STAR NPL) plants and microbes as a source of new natural products derived compounds, enzymes and drug candidates to advance our knowledge of the nature and the development of new pharmaceuticals, agrochemicals, functional foods, flavourings, cosmetics and personal care sectors. These studies require the use and continued improvement of chromatographic (HPLC), spectroscopic (High Resolution Mass Spectrometry, 1H and 2D Nuclear Magnetic Resonance) and chemical modification (degradation, derivatization and biotransformation), supported by a wide array of biochemical or cellular assays. In addition, the compounds isolated from these natural sources, forms a purified compound library, which is also managed and maintained by the group.
More Details

Selected Publications
  1. Faezeh Monjia, Lang Chu Laua, Abrar Al-Mahmood Siddiqueea, Baharudin Bin Saida, Lay-Kien Yangb, Yoganathan K.b, Mahesh A. Choolania, P. Ganesan Adaikana.
    Potent tocolytic activity of ethyl acetate fraction of Ananas comosus on rat and human uteri.
    Accepted 4 June 2018 Biomedicine & Pharmacotherapy,

  2. Wang X, Roberstson A L, Li, JY Chai R, Haishan W, Sadiku P, Ogryzko NV, Everett M, Yoganathan K, Luo H R, Renshaw S A and Ingham P W.
    Novel natural product inhibitors of neutrophil recruitment identified through a transgenic zebrafish screen.
    (2014) Disease Models & Mechanisms, 7(1), 163-169.
    PubMed PMID: 24291762.

  3. Butler M S, Yoganathan K, Buss A D and Ng SB.
    Identification of aluminium dioxalate in fungal cultures grown on vermiculite.
    (2012) Journal of Antibiotics, 65, 275-278.
    PubMed PMID: 22415460.

  4. Nguyen T M, Vu N Q, Youte JJ, Jacelyn L, Cheong A, Ho Y S, Tan B S W, Yoganathan K, Butler M S and Chai CLL.
    A fast and straightforward route towards the synthesis of the lissoclimide class of anti-tumour agents.
    (2010) Tetrahedron, 66, 9270-9276.

  5. Yoganathan K, Cao S, Crasta C S, Aitipamula S, Whitton S R, Ng S B, Antony D, Buss A D, Mark S, Butler M S.
    Microsphaerins A–D, four novel benzophenone dimers with activity against MRSA from the fungus Microsphaeropsis sp.
    (2008) Tetrahedron, 64, 10181-10187.

  6. Mach B, Traxler P, Masternak K, Buss A D, Whitton S R, Butler M S, Yoganathan K, Flotow H, Guo X, Sim M M, Phoon C W.
    Macrolide as inhibitors of MHC Class II.
    (2007) Novimmune: WO 2007/110705A2.
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