Principal Investigator Position in Computational/Statistical Genomics

The Genome and Gene Expression Data Analysis Division at the Bioinformatics Institute (BII), Agency of Science and Technology Research (A*STAR), Republic of Singapore, invites applications for a junior or senior principal-investigator (PI) position in the area of computational/statistical applications in genomics. The successful candidate will establish and lead an independent research team in the division that spearheads the data analysis/data mining/modelling/algorithm development projects, working closely with biologists and bioinformaticians.

BII has a strong focus on internationally competitive fundamental research as well as on translational outreach towards clinical and industrial applications. The Genome and Gene Expression Data Analysis Division is multi-disciplinary with a wide range of expertise in computational biology applied to nucleic acid sequences, expression profiles and RNA biology and its relevance with regard to clinical medicine. The goal is to bridge genomics, transcriptomics and biomedical studies through the development and application of computational biology and systems biology approaches, probabilistic modelling and simulations. Advanced computer and certain experimental facilities are available within BII.

Interested candidates with the following credentials may send an email application to Dr. Vladimir Kuznetsov:

• Ph.D. degree in a relevant area (e.g., computational biology, systems biology, discrete mathematics, statistics, biophysics) and a notable publication record.
• Strong analytical skills, especially in the area of large data set analysis and statistical applications.
• Good programming experience (e.g., Java, C/C++, R, S-plus, SQL, Java, Oracle, website and database experience).
• Experienced in combining computational methodologies with biological experimental work to further biological discoveries.

Interested applicants should send their CV, statement of research interests and the names and addresses of three references. The application is expected to be accompanied with the outline of a research project that the applicant plans to work on during his time as PI in BII. Possible projects might involve multivariate transcriptome and genome data analysis, protein-DNA interactions, DNA-RNA interaction, modelling and prediction of complex interaction networks, computational algorithms for nucleic sequence interaction analysis, analysis and prediction of ncRNAs, identification of biomarkers associations with cellular phenotypes and human diseases (in addition to other topics). You are expected to use and develop probabilistic models, combinatorial algorithms, and statistical methods and implement them in computer programs, large-scale calculations and predictions. We are looking for a candidate who is independent-minded, can work well in a team environment, and willing to collaborate with experimental laboratories.

The job scope includes:

• Application of genome sequence and expression profile analysis to a relevant biological or clinical problem with the goal of elucidating genome-phenotype relationships and the mechanisms linking the two.
• Recruit and lead an independent group.
• Involvement in education of PhD students and, to a minor degree, of MSc students.

The position provides a three-year unlimitedly renewable contract with competitive benefits. The search will continue until the position is filled (at least until 30th June 2012). For more information, please visit our website at http://www.bii.a-star.edu.sg/research/gagd/gagd.php. Applications and inquiries should be sent to Dr. Vladimir Kuznetsov (vladimirk@BII.a-star.edu.sg).